Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology

Ferber, Dyke; S. M. El Nahhas, Omar; Wölflein, Georg; C. Wiest, Isabella; Clusmann, Jan; Leßmann, Marie-Elisabeth; Foersch, Sebastian; Lammert, Jacqueline; Tschochohei, Maximilian; Jaeger, Dirk; Salto‐Tellez, Manuel; Schultz, Nikolaus; Truhn, Daniel; Nikolas Kather, Jakob

doi:10.1038/s43018-025-00991-6

Public

Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology

Published in Nature Cancer • Jun 6, 2025

Authors:

Dyke Ferber

Omar S. M. El Nahhas

Georg Wölflein

Abstract

Clinical decision-making in oncology is complex, requiring the integration of multimodal data and multidomain expertise. We developed and evaluated an autonomous clinical artificial intelligence (AI) agent leveraging GPT-4 with multimodal precision oncology tools to support personalized clinical dec...

Subject

Artificial intelligence

Clinical decision making

Computer science

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