Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer

Uppaluri, Ravindra; I. Haddad, Robert; Tao, Yungan; Le Tourneau, Christophe; Y. Lee, Nancy; H. Westra, William; D. Chernock, Rebecca; Tahara, Makoto; J. Harrington, Kevin; L Klochikhin, A; Braña, Irene; Vasconcelos Alves, Gustavo; Hughes, Brett; Oliva, Marc; Pinto Figueiredo Lima, Iane; Ueda, Tsutomu; A. Rutkowski, Tomasz; C. Schroeder, Ursula; Mauz, Paul‐Stefan; Fuereder, Thorsten; Laban, Simon; Oridate, Nobuhiko; Popovtzer, Aron; Mach, Nicolas; Korobko, Yevhen; Alpuim Costa, Diogo; Hooda-Nehra, Anupama; P. Rodriguez, Cristina; Bryan Bell, R.; Manschot, Cole; Benjamin, Kimberly; Gümüşçü, Burak; Adkins, Douglas

doi:10.1056/nejmoa2415434

Public

Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer

Published in New England Journal of Medicine • Jun 18, 2025

Authors:

Ravindra Uppaluri

Robert I. Haddad

Yungan Tao

Abstract

BACKGROUND: The benefit of the addition of perioperative pembrolizumab to standard care with surgery and adjuvant therapy for patients with locally advanced head and neck squamous-cell carcinoma (HNSCC) is unclear. METHODS: In this phase 3, open-label trial, we randomly assigned participants with lo...

Subject

Pembrolizumab

Medicine

Head and neck squamous-cell carcinoma

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