Synthesis and biological characterization of dual-specific proteolysis target chimeras (PROTACs) for the kinases FLT3-ITD and MAPK14 with antileukemic activity

Abdelsalam, Mohamed; Halilovic, Melisa; Ashry, Ramy; Nassar, Husam; Schmidt, Matthias; H. Krämer, Oliver; Sippl, Wolfgang

doi:10.26434/chemrxiv-2025-f0cxr

Public

Synthesis and biological characterization of dual-specific proteolysis target chimeras (PROTACs) for the kinases FLT3-ITD and MAPK14 with antileukemic activity

Published in ChemRxiv • Jun 24, 2025

Authors:

Mohamed Abdelsalam

Melisa Halilovic

Ramy Ashry

Abstract

Acute myeloid leukemia (AML) is a hematological malignancy frequently driven by mutations in the FLT3 gene, particularly internal tandem duplications (FLT3-ITD), which contribute to aberrant cell proliferation and resistance to tyrosine kinase inhibitors (FLT3i). The limitations of current FLT3i the...

Subject

Proteolysis

Kinase

Cell biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!