CAR-T cell therapy for cancer: current challenges and future directions

Zugasti, Inés; Espinosa-Aroca, Lady; Fidyt, Klaudyna; Mulens‐Arias, Vladimir; Díaz‐Beyá, Marina; Juan, Manel; Urbano-Ispizúa, Álvaro; Esteve, Jordi; Velasco-Hernández, Talía; Menéndez, Pablo

doi:10.1038/s41392-025-02269-w

Public

CAR-T cell therapy for cancer: current challenges and future directions

Published in Signal Transduction and Targeted Therapy • Jul 3, 2025

Authors:

Inés Zugasti

Lady Espinosa-Aroca

Klaudyna Fidyt

Abstract

Chimeric antigen receptor T (CAR-T) cell therapies have transformed the treatment of relapsed/refractory (R/R) B-cell malignancies and multiple myeloma by redirecting activated T cells to CD19- or BCMA-expressing tumor cells. However, this approach has yet to be approved for acute myeloid leukemia (...

Subject

Chimeric antigen receptor

Medicine

Cancer research

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