Efficient and sustained optogenetic control of sensory and cardiac systems

Alekseev, Alexey; Hunniford, Victoria; Zerche, Maria; Jeschke, Marcus; El May, Fadhel; Vavakou, Anna; Siegenthaler, Dominique; A. Hüser, Marc; M Kiehn, Svenja; Garrido‐Charles, Aida; Meyer, Alexander; Rambousky, Adrian; Alvanos, Theocharis; Witzke, Isabel; Dara Rojas-García, Keila; D Draband, Martin; Cyganek, Lukas; Klein, Eric; Ruther, Patrick; Huet, Antoine; Trenholm, Stuart; Macé, Émilie; Kusch, Kathrin; Bruegmann, Tobias; Wolf, Bettina; Mager, Thomas; Moser, Tobias

doi:10.1038/s41551-025-01461-1

Public

Efficient and sustained optogenetic control of sensory and cardiac systems

Published in Nature Biomedical Engineering • Jul 28, 2025

Authors:

Alexey Alekseev

Victoria Hunniford

Maria Zerche

Abstract

Optogenetic control is used to manipulate the activity of specific cell types in vivo for a variety of biological and clinical applications. Here we report ChReef, an improved variant of the channelrhodopsin ChRmine. ChReef offers minimal photocurrent desensitization, a unitary conductance of 80 fS ...

Subject

Optogenetics

Channelrhodopsin

Neuroscience

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