Ultra-performance liquid chromatography-mass spectrometry analysis of post-mortem brain tissue reveals specific amino acid profile dysregulation in Parkinson’s Disease and Alzheimer’s Disease patients

Gervasoni, Jacopo; Maio, Anna; Serra, Marcello; Cicchinelli, Michela; Santucci, Lavinia; Ciasca, Gabriele; Nuzzo, Tommaso; Li, Qin; Thiolat, Marie-Laure; Morelli, Micaela; Urbani, Andrea; Errico, Francesco; Bézard, Erwan; Usiello, Alessandro

doi:10.1101/2025.07.22.666071

Public

Ultra-performance liquid chromatography-mass spectrometry analysis of post-mortem brain tissue reveals specific amino acid profile dysregulation in Parkinson’s Disease and Alzheimer’s Disease patients

Published in bioRxiv (Cold Spring Harbor Laboratory) • Jul 25, 2025

Authors:

Jacopo Gervasoni

Anna Maio

Marcello Serra

Abstract

Abstract Background Combined metabolomic and HPLC-based analyses have identified significant metabolic alterations in serum and plasma amino acid levels of Parkinson’s disease (PD) patients, underscoring their potential as biomarkers. However, it remains unclear whether these biochemical changes als...

Subject

Disease

Mass spectrometry

Parkinson's disease

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