Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia

Marchi, Francisco; M. Shastri, Vivek; J Marrero, Richard; Nguyen, Nam; Öttl, Antonella; Schade, Ann-Kathrin; Landwehr, Marieke; Krali, Olga; Nordlund, Jessica; Ghavami, Matin; Sckaff, Fernando; K. Mansinghka, Vikash; Cao, Xueyuan; B. Slayton, William; Starostik, Petr; R. Cogle, Christopher; C. Ribeiro, Raul; E. Rubnitz, Jeffrey; M. Klco, Jeffery; Elsayed, Abdelrahman; S. Gamis, Alan; J. Triche, Timothy; E. Ries, Rhonda; Anders Kolb, E.; Aplenc, Richard; A. Alonzo, Todd; Pounds, Stanley; Meshinchi, Soheil; K. Lamba, Jatinder

doi:10.1038/s41467-025-62005-4

Public

Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia

Published in Nature Communications • Jul 29, 2025

Authors:

Francisco Marchi

Vivek M. Shastri

Richard J Marrero

Abstract

Despite the critical role of DNA methylation, clinical implementations harnessing its promise have not been described in acute myeloid leukemia. Utilizing DNA methylation from 3314 leukemia patient samples across 11 harmonized cohorts, we describe the Acute Leukemia Methylome Atlas, which includes r...

Subject

Epigenomics

Myeloid leukemia

DNA methylation

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