Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer

J. Neill, Nicholas; Satpathy, Shankha; Krug, Karsten; K. Meena, Jitendra; Ramesh Babu, Nivetha; Calderon, Cheyenne; J. Reed, Donald; Weber, Martin; E. Dobrolecki, Lacey; Lewis, Alaina; Sallas, Christina; Anurag, Meenakshi; R. Holloway, Kimberly; Huang, Chen; Vasaikar, Suhas; F. Cardenas, Maria; Kim, Beom-Jun; W. Chan, Doug; C. Avanessian, Shayan; Tyagi, Siddhartha; Orellana, Mayra; Mao, Sufeng; Li, Heyuan; Gong, Fade; J. Kurley, Sarah; L. Meerbrey, Kristen; M. Olson, Calla; Nair, Amritha; Sun, Tingting; Chung, Hsiang-Ching; A. Bowling, Elizabeth; H. Wang, Jarey; Zhang, Pengju; Xiao, Peng; Yang, Duxiao; Stossi, Fabio; C. Polley, Mei‐Yin; B. Saltzman, Alexander; Mundt, Filip; Mani, D.R.; A. Gillette, Michael; G. Hilsenbeck, Susan; Miles, George; Gutiérrez, Carolina; Kent Osborne, C.; Y. Lin, Charles; S. Gray, Nathanael; Sun, Jin‐Peng; A. Wheeler, David; M. Perou, Charles; Malovannaya, Anna; T. Lewis, Michael; Zhang, Bing; J. Ellis, Matthew; A. Carr, Steven; F. Westbrook, Thomas

doi:10.1158/2159-8290.cd-23-1173

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Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer

Published in Cancer Discovery • Aug 8, 2025

Authors:

Nicholas J. Neill

Shankha Satpathy

Karsten Krug

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with few effective targeted therapies. Taxanes and other microtubule-targeting agents (MTA) are first-line chemotherapies for TNBC; however, the molecular mechanisms that underlie TNBC taxane sensitivity are largely unkno...

Subject

Triple-negative breast cancer

Cancer research

Taxane

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