Insights into Parkinson’s Disease Pathology Focusing on Glial Response and Apoptosis in a Classic Rat Model of Dopaminergic Degeneration

Aurélio M. Freire, Marco; S. Rocha, Gabriel; A. M. Lemos, Nelson; Rodrigues Lima, Rafael; Bittar, Stanley; B. Jenkins, Lissandra; Falcão, Daniel; W.M. Steinbusch, Harry; Ronaldo dos Santos, José

doi:10.3390/neuroglia6030036

Public

Insights into Parkinson’s Disease Pathology Focusing on Glial Response and Apoptosis in a Classic Rat Model of Dopaminergic Degeneration

Published in Neuroglia • Sep 18, 2025

Authors:

Marco Aurélio M. Freire

Gabriel S. Rocha

Nelson A. M. Lemos

Abstract

Background/Objectives: Parkinson’s disease (PD) is the second-most prevalent neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc). Experimental models that replicate core features of PD are critical to investigate unde...

Subject

Pars compacta

Substantia nigra

Dopaminergic

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