Sequential Combination of Unfavorable Histology, Followed by Clinical Stage M, Defines High-Risk Neuroblastoma: A Report from the Children’s Oncology Group

K. Hazard, Florette; M.S. Toland, Angus; Y. Tan, Serena; Chiu, Bill; Ikegaki, Naohiko; Naranjo, Arlene; L. Cohn, Susan; B. London, Wendy; M. Gastier‐Foster, Julie; C. Ramirez, Nilsa; C. Reshmi, Shalini; Wagner, Eva; G. Nuchtern, Jed; Asgharzadeh, Shahab; Marachelian, Araz; M. Maris, John; Bagatell, Rochelle; R. Park, Julie; S. Irwin, Meredith; D. Hogarty, Michael; Shimada, Hiroyuki

doi:10.1158/1078-0432.ccr-24-4369

Public

Sequential Combination of Unfavorable Histology, Followed by Clinical Stage M, Defines High-Risk Neuroblastoma: A Report from the Children’s Oncology Group

Published in Clinical Cancer Research • Oct 27, 2025

Authors:

Florette K. Hazard

Angus M.S. Toland

Serena Y. Tan

Abstract

PURPOSE: Historically, neuroblastoma risk stratification has been performed with clinical stage as the starting point and successively adding other prognostic factors thereafter. This study takes an alternative approach to define risk groups of patients with neuroblastoma by starting with the Intern...

Subject

Medicine

Stage (stratigraphy)

Oncology

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