Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T-cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite-Stable Colorectal Cancer

Fumet, Jean-David; Latour, Charlène; Nuttin, Lisa; Dérangère, Valentin; Ilie, Alis; Paolo Di Russo, Pier; Hampe, Léa; Daumoine, Susy; Thibaudin, Marion; Truntzer, Caroline; Ghiringhelli, François; Limagne, Emeric

doi:10.1158/0008-5472.can-25-0079

Public

Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T-cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite-Stable Colorectal Cancer

Published in Cancer Research • Nov 6, 2025

Authors:

Jean-David Fumet

Charlène Latour

Lisa Nuttin

Abstract

Immune checkpoint blockade treatment is highly effective in microsatellite-instable (MSI) colorectal cancer. However, microsatellite-stable (MSS) tumors, which represent 95% of metastatic colorectal cancer, are intrinsically resistant to immunotherapy. In this study, we sought to better understand t...

Subject

Blockade

Colorectal cancer

Medicine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!