Biochemical Modifications of Homocysteine Drive Neutrophil Extracellular Trap Formation in Ischemic Stroke

S Nair, Aswathy; Yedehalli Thimmappa, Pooja; Babu Jasti, Dushyanth; Arvin Rodrigues, Joel; Gangadharan, Gireesh; Sivakumar, G; R. Nagareddy, Prabhakara; N Shivashankar, K; Umakanth, Shashikiran; B. Joshi, Manjunath

doi:10.1096/fj.202500844rr

Public

Biochemical Modifications of Homocysteine Drive Neutrophil Extracellular Trap Formation in Ischemic Stroke

Published in The FASEB Journal • Nov 13, 2025

Authors:

Aswathy S Nair

Pooja Yedehalli Thimmappa

Dushyanth Babu Jasti

Abstract

Excessive production of neutrophil extracellular traps (NETs) contributes to immunothrombosis activation in ischemic stroke pathogenesis. The metabolic and mechanistic regulators of NET formation in relation to platelet activation during ischemic stroke remain poorly understood. In the present study...

Subject

Neutrophil extracellular traps

Homocysteine

Hyperhomocysteinemia

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