Clinicogenomic Characterization of Primary Sclerosing Cholangitis–Associated Biliary Tract Cancers

Wang, Xin; Haro-Silerio, Jaime; E.G. Beaudry, Felix; Borgida, Ayelet; Abbas‐Aghababazadeh, Farnoosh; Bondar. Sahebi, Nasim; Wang, Michael; P. Fox, Daniel; Nuh, Mohamed; Hsiang, Monica; Bhamidipati, Deepak; C. Kang, Hyunseon; Cox, Veronica; B. Ludmir, Ethan; J. Koay, Eugene; N. Kwong, Lawrence; Quentin, Kimana; Chatterjee, Deyali; Shin Chun, Yun; S. Tran Cao, Hop; Meric‐Bernstam, Funda; Hu, Ian; Dodd, Anna; Hamza, Oumaima; Hildebrand, Maggie; Bucur, Roxana; M. Hirschfield, Gideon; Vogel, Arndt; M. O’Kane, Grainne; Gallinger, Steven; Haibe‐Kains, Benjamin; Notta, Faiyaz; Sapisochín, Gonzalo; J. Knox, Jennifer; Javle, Milind; S. Lee, Sunyoung; C. Grant, Robert

doi:10.1158/1078-0432.ccr-25-1834

Public

Clinicogenomic Characterization of Primary Sclerosing Cholangitis–Associated Biliary Tract Cancers

Published in Clinical Cancer Research • Nov 18, 2025

Authors:

Xin Wang

Jaime Haro-Silerio

Felix E.G. Beaudry

Abstract

PURPOSE: Biliary tract cancer (BTC) is the leading cause of death in patients with primary sclerosing cholangitis (PSC). PSC-related BTC is poorly understood, and the risks and benefits of conventional and immunotherapy treatments are unknown. We aimed to characterize clinical outcomes and genomes o...

Subject

Medicine

Biliary tract cancer

Biliary tract

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