CD47-Sirpa blockade enhances antitumor activity against mouse liver cancer by boosting cDC2 functions 4531

Abstract Description The CD47-SIRPα axis functions as an immune checkpoint, transmitting a “don’t eat me” signal to prevent macrophage-mediated phagocytosis of tumor cells. While CD47 is expressed on most immune cells and is highly induced in tumor cells, SIRPα is expressed on phagocytes, including ... View More