Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis

Ben Okon, Michael; Victor Fasogbon, Ilemobayo; Swase, Dominic; Samson Dangana, Reuben; Makena, Wusa; Onyinye Ojiakor, Vivian; Monday Etukudo, Ekom; Chebet, Joan; Mumbua Musyoka, Angela; Etumah Ifie, Sandra; Mbyemeire, Herbert; Adomi Mbina, Solomon; Paul-Chima Ugwu, Okechukwu; Oviosun, Augustine; Michael Usman, Ibe; Eseoghene Ifie, Josiah; Rangasamy, Loganathan; Sinbad Olorunnisola, Olubukola; Mounmbegna, Philippe; Noreen, Sana; Maduabuchi Aja, Patrick

doi:10.3389/ftox.2025.1687862

Public

Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis

Published in Frontiers in Toxicology • Nov 24, 2025

Authors:

Michael Ben Okon

Ilemobayo Victor Fasogbon

Dominic Swase

Abstract

Introduction Bisphenol A (BPA), a pervasive endocrine-disrupting chemical, impairs male reproductive health via oxidative stress, hormonal dysregulation, and hypothalamic–pituitary–gonadal (HPG) axis disruption. Flavonoids, widely present in plant-derived foods and medicinal herbs, possess antioxida...

Subject

Oxidative stress

Endocrine system

Hormone

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