Glycogen-Linked TPGS Nanomicelles for Hypoxia-Responsive PD-L1 Targeting and Molecular Imaging of Breast Tumor

Vinodrao Randhave, Nandini; Tamang, Rupen; Setia, Aseem; Kumar Mehata, Abhishesh; Koch, Biplob; S. Muthu, Madaswamy

doi:10.1021/acsbiomaterials.5c01386

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Glycogen-Linked TPGS Nanomicelles for Hypoxia-Responsive PD-L1 Targeting and Molecular Imaging of Breast Tumor

Published in ACS Biomaterials Science & Engineering • Nov 30, 2025

Authors:

Nandini Vinodrao Randhave

Rupen Tamang

Aseem Setia

Abstract

In the present work, we have modified glycogen (GLY) with D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via the esterification reaction to obtain an amphiphilic polymer (TPGS-GLY). The TPGS-GLY conjugation was confirmed by FTIR and MALDI spectrometry. Furthermore, we prepared polymeric na...

Subject

Cytotoxicity

Chemistry

Polyethylene glycol

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