Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding

C. Reade, Michael; C. Marks, Denese; Howe, Belinda; Bailey, Michael; G. Bannon, Paul; M. Eastwood, Glenn; French, Craig; Gattas, David; M. Higgins, Alisa; Holley, Anthony; Hu, Raymond; O. Irving, David; Johnson, Lacey; McGuinness, Shay; McQuilten, Zoe; Royse, Alistair; A. Smith, Julian; Weinberg, Laurence; M. Wood, Erica; Buckland, Mark; Bedaton, Grace; Neylan, Aimee; Robertshaw, Sarah; Tran, Huyen; Ueoka, Mayumi; Wallace, Sophia; Bickerton, Tayla; Kavadias, Penny; Macfarlane, Chanelle; Shackles, Jocelyn; Veljanovski, Teodora; Webb, Andrew; Weinberg, Laurence; Baulch, Sarah; Bellomo, Rinaldo; Claxton, Gayle; Eastwood, G; Harris, Saskia; Hu, Raymond; Makar, Tim; Peck, Leah; Sidiropoulos, Sofia; Young, Helen; Ambanloc, Shevonne; Banchi, S; Banks, Louise; Davies, Alison; Gao, Yanan; Gazelle, Rebecca; Hogan, Chris; Kannesan, Darshini; Kelly, Sean; Kolar, Diana; Leong, Cheng; Masuku, Pride; Napoles, Ranniette; Ng, James; Oldenburger, Catherine; Rodrigues, Chris; Saberi, Mehdi; Tran, Khue; Usón, M; Wilkes, Anne‐Marie; P. McCullough, James; Gough, Maimoonbe; Houbert, Maree; Pitman, Julie; Tallott, Mandy; Betts, Christina; McMahon, Shanne; O'Loughlin, Quirine; Weng, Alex; Aneman, Anders; Coupland, Lucy; Le, Thi; Miller, Jennene; Wp, O'regan; Pancholi, Amit; Shaw, David; Dhir, Vimlesh; Matta, Louise; Moyo, Norah; G Royse, A; Balcos, Paul; Boggett, Stuart; Royse, Colin; Williams, Zelda; Wu, Jingfei; Bisignano, Maria; Haeusler, Michael; Neander, E; Nguyen, Van; Nt, Pham; Smith, Katie; Snowdon, Madeleina; Gattas, David; Beattie, Lorna; Buhr, Heidi; Cartwright, Bruce; Coles, Jennifer; Evangelisti, Olivia; Liang, Yi; Oostveen, Carmel; Turner, Lisa; Ackermann, Lynette; Zr, Anwar; Flinn, H; Lee, Rachael; Pulanco, Cindy; Skidmore, Jan; Teevan, Jasmin; Slater, Ben; Corcoran, Petrea; Fernandez, Amanda; Hall, Katrina; Pappas, Paige; Scott, D.; Cole-Sinclair, Merrole; Crockett, Rebecca; Morris, Kimberley; Walter, Carmen; Pearse, B; O'brien, Donalee; Amerio, Emily; Boyd, Melanie; Jacobus H de Waard, C; Mehta, Ami; Vincent, Billy; Whiteside, Joanna; Win, April; Baker-Pearson, Iris; Senthuran, Siva; Brown, Carley; Gofton, C; Kempshall, Laurence; Lakh, Sonya; McCormack, Sophie; Marshall, Hayley; Mills, Wayde; Patane, Maria; Rice, Tenille; Sawyer, Natalie; Shucksmith, Maria; Smith, Julian; Hulley, Amanda; Kim, Martin; Warwarek, Sarah; Fossaert, Leonardo; Juliana, Juliana; Hu, Songchen; Koralegedara, Kanchanamala; Papasimeon, Vana; Reid, Sharon; Santamaria, Mara; Singh, Harneek; Sreng, Chanarong; JM, Dieleman; (Emma) Lei, Lei; Ali, Farheen; Clark-Mackay, Eleanore; Cope, Jennifer; Hinks, P; Hussain, Shafiqa; Mateus Crew, Jasmine; Medalla, Hazel; Nderitu Mungai, Tabitha; Pasalic, Leonardo; Shaktour, Tahini; van de Vorstenbosch, Emma; Wentworth, Avril; Bailey, Michael; Paul, E; Tan, Shereen

doi:10.1001/jama.2025.23355

Public

Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding

Published in JAMA • Dec 9, 2025

Authors:

Michael C. Reade

Denese C. Marks

Belinda Howe

Abstract

Importance: Liquid-stored platelets have a shelf-life of 5 to 7 days, limiting availability and resulting in wastage. Objective: To assess the effectiveness and safety of dimethyl sulfoxide-cryopreserved platelets, which have a shelf-life of 2 years, as a treatment for cardiac surgery bleeding. Desi...

Subject

Medicine

Cryopreservation

Surgery

Research Assistant

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