Design and Synthesis of Thiadiazole Derivatives as Dual EGFR/COX-2 Inhibitors with Anticancer and Anti-inflammatory Activities

Hıdır, Arzu; Osmani̇ye, Derya; Nurpelin Sağlık, Begüm; Levent, Serkan; Asım Kaplancıklı, Zafer; Özkay, Yusuf

doi:10.1021/acsomega.5c09752

Public

Design and Synthesis of Thiadiazole Derivatives as Dual EGFR/COX-2 Inhibitors with Anticancer and Anti-inflammatory Activities

Published in ACS Omega • Dec 12, 2025

Authors:

Arzu Hıdır

Derya Osmani̇ye

Begüm Nurpelin Sağlık

Abstract

High Resolution Image Download MS PowerPoint Slide In this study, 20 new compounds with thiadiazole structures were synthesized based on Alpelisib. The benzene ring, a bioisostere of the pyridine ring in the lead compound, was used in the synthesized compounds, and derivatives containing different s...

Subject

Bioisostere

Chemistry

Combinatorial chemistry

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