TGF-βRII/IL-15 immunotherapeutic complex targets exhausted CD8 <sup>+</sup> T-cell subsets in lymph nodes and tumors

K George, Varghese; C Wong, Hing; Felices, Martin; P Rubinstein, Mark; Shrestha, Niraj; Valderrama, Natalia; Farzaneh, Hamidreza; Kong, Lin; Gilkes, Crystal; Thompson, Alyssa; Larson, Megan; Liu, Bai; Zhu, Xiaoyun; Michel Leclerc, Gilles; Chung, Dongjun; Xie, Juan; Krull, Jordan; Gomez, Lucas; Kanakaraj, Leah; Bialik, Ann; O Egan, Jack; You, Lijing; Liu, Xianglan; Teodorescu, Rachael; K Karen Gutierrez, Ana; Echeverri, Christian; Rodriguez, Reynier; Wang, Zheng; Xing, Jilan; Gonzalez, Neicy; Chaturvedi, Pallavi; R Patel, Manish; Wangen, Rose; Cao, Qing; R Rhode, Peter; S Miller, Jeffrey; A Geller, Melissa

doi:10.1136/jitc-2025-013533

Public

TGF-βRII/IL-15 immunotherapeutic complex targets exhausted CD8 + T-cell subsets in lymph nodes and tumors

Published in Journal for ImmunoTherapy of Cancer • Dec 1, 2025

Authors:

Varghese K George

Hing C Wong

Martin Felices

Abstract

Background Stem-like progenitor exhausted CD8 + T cells (T PEX ), located within the tumor-draining lymph nodes (TDLNs), are responsible for maintaining tumor-specific responses in cancer. Although cytokines such as interleukin (IL)-15 are known to expand CD8 + T-cell subsets, transforming growth fa...

Subject

Medicine

Lymph

Cancer research

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