Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain

Sapp, Ellen; B. Kegel, Kimberly; Aronin, Neil; Hashikawa, Tsutomu; Uchiyama, Yasuo; Tohyama, Koujiro; G. Bhide, Pradeep; G. Vonsattel, J.-P.; DiFiglia, Marian

doi:10.1093/jnen/60.2.161

Public

Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain

Published in Journal of Neuropathology & Experimental Neurology • Feb 1, 2001

Authors:

Ellen Sapp

Kimberly B. Kegel

Neil Aronin

Abstract

Microglia may contribute to cell death in neurodegenerative diseases. We studied the activation of microglia in affected regions of Huntington disease (HD) brain by localizing thymosin beta-4 (Tbeta4), which is increased in reactive microglia. Activated microglia appeared in the neostriatum, cortex,...

Subject

Microglia

Huntington's disease

Neuroscience

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