Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development

Wiszniak, Sophie; Alankarage, Dimuthu; Lohraseb, Iman; Marchant, Ceilidh; Secker, Genevieve; Domingo, Deepti; Hartmann, Jasmine; Zhang, Tianyang; Parker, Wendy; Toubia, John; White, Melissa; Piltz, Sandra; Tondl, Markus; Giannoulatou, Eleni; Winlaw, David; M. Blue, Gillian; Heart Disease Synergy Group, Congenital; Kirk, Edwin; Chapman, Gavin; Nassar, Natasha; Sholler, Gary; Lain, Samantha; P. L. Tam, Patrick; Thomas, Paul; Harvey, Natasha; L. Dunwoodie, Sally; Schwarz, Quenten

doi:10.1038/s41467-026-68459-4

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Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development

Shared by NobleBlocks on Jan 22, 2026 • 12:00 AM UTC

Authors:

Sophie Wiszniak

Dimuthu Alankarage

Iman Lohraseb

Abstract

Abstract Cardiac outflow tract morphogenesis requires coordinated interactions between multiple cell populations and is dependent on the contribution of cardiac progenitors from the second heart field. While neural crest cells have been proposed to impact second heart field development, how they reg...

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