A new tunable 3D alveolospheres model from human alveolar epithelial type 2 cells (AEC2) with reduced heterogeneity for studying cigarette smoke extract exposure

Guecamburu, Marina; Pavot, Arthur; Legrix, Amélie; Jeannière, Caroline; Belaroussi, Yaniss; Thumerel, Matthieu; Samaniego, Emma; Begueret, Hugues; Maucort, Guillaume; Decoeur, Fanny; Dupuy, Jean-William; Raymond, Anne-Aurélie; Esteves, Pauline; Grassion, Leo; Dournes, Gael; Berger, Patrick; Maurat, Elise; Raasch, Katharina; Latouille, Eloïse; Studer, Vincent; Dupin, Isabelle; Henrot, Pauline; Zysman, Maéva

doi:10.1186/s12931-026-03628-z

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A new tunable 3D alveolospheres model from human alveolar epithelial type 2 cells (AEC2) with reduced heterogeneity for studying cigarette smoke extract exposure

Shared by NobleBlocks on Mar 17, 2026 • 12:00 AM UTC

Authors:

Marina Guecamburu

Arthur Pavot

Amélie Legrix

Abstract

Abstract Rationale Three-dimensional (3D) organoid models, such as alveolospheres, are unique tools for investigating the mechanisms underlying emphysema. However, high inter-organoid heterogeneity hampers consistent results in emphysema research and drug testing. Objectives To develop a tunable 3D ...

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