The role of sperm DNA fragmentation testing in predicting IVF and PGT-A outcomes

Okubo, Tsuyoshi; Kobayashi, Tatsuya; Hayashi, Teruaki; Onda, Noriyuki; Omi, Kenji; Segawa, Tomoya

doi:10.1038/s41598-026-38974-x

Public

The role of sperm DNA fragmentation testing in predicting IVF and PGT-A outcomes

Published in Scientific Reports • Mar 23, 2026

Authors:

Tsuyoshi Okubo

Tatsuya Kobayashi

Teruaki Hayashi

Abstract

This retrospective study evaluated whether sperm DNA fragmentation (SDF), measured by DNA fragmentation index (DFI), predicts IVF outcomes in 124 couples undergoing IVF with PGT-A (Preimplantation Genetic Testing for Aneuploidy) between 2015 and 2023. SDF was assessed using the Halosperm kit and cat...

Subject

DNA fragmentation

Andrology

Aneuploidy

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