Abstract 3212: Enhancing the detection of circulating tumor DNA by combining Interlace™ global methylation discovery with next-generation sequencing test Labcorp Plasma Complete™

A. Holden, Kimberly; Maddox, Cynthia; Mould, Calum; Mensah, Nana; Tosti, Luca; Pieniak, Iwo; Siejka-Zielińska, Paulina; Evans, S.; Lucarelli, Debora; Neely, Robert; C. Smith, Anthony; C. Valkenburg, Kenneth; Eisenberg, Marcia; Caveney, Brian; Severson, Eric; J. Jensen, Taylor; Ramkissoon, S.; Williams, Jonathan

doi:10.1158/1538-7445.am2026-3212

Public

Abstract 3212: Enhancing the detection of circulating tumor DNA by combining Interlace™ global methylation discovery with next-generation sequencing test Labcorp Plasma Complete™

Published in Cancer Research • Apr 3, 2026

Authors:

Kimberly A. Holden

Cynthia Maddox

Calum Mould

Abstract

Abstract Genome-wide methylation patterns are a powerful biomarker. The detection of aberrant methylation has many oncological applications, including using tumor DNA for cancer detection and therapy selection. In liquid biopsies, the ability to detect small amounts of circulating tumor DNA (ctDNA) ...

Subject

CpG site

Cancer

Circulating tumor cell

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