A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: vaginal cancer sub cohort results

Kwang Chae, Young; Czeskleba, Josie; Pravin Patel, Sandip; Mentor, Alex; Robinson, William; Jones, Nathaniel; Rampurwala, Murtuza; Naing, Aung; M. Beck, Joseph; Moloney-Lineen, Carolyn; Il‐Young Chung, Liam; M. McLeod, Christine; Y. Chen, Helen; Sharon, Elad; Threlkel, Sara; Othus, Megan; W. Ryan, Christopher; D. Blanke, Charles; Kurzrock, R.

doi:10.3802/jgo.2026.37.e92

Public

A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: vaginal cancer sub cohort results

Published in Journal of Gynecologic Oncology • Jan 1, 2026

Authors:

Young Kwang Chae

Josie Czeskleba

Sandip Pravin Patel

Abstract

OBJECTIVE: The SWOG S1609 Dual Anti-CTLA-4 & Anti-PD-1 blockade in Rare Tumors (DART) trial is the first basket study to include a sub-cohort assessing ipilimumab and nivolumab in patients with primary vaginal cancers with differing histology. METHODS: DART is a prospective, open-label, multicenter,...

Subject

Medicine

Nivolumab

Ipilimumab

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