Monte Carlo simulations identify suboptimal PK/PD target attainment with standard maribavir dosing.

Fromage, Yeleen; Sayadi, Hamza; Labriffe, Marc; Codde, Cyrielle; Alain, Sophie; Marquet, Pierre; Woillard, Jean-Baptiste; Monchaud, Caroline

doi:10.1093/jac/dkag153

Public

Monte Carlo simulations identify suboptimal PK/PD target attainment with standard maribavir dosing.

Shared by NobleBlocks on May 5, 2026 • 12:00 AM UTC

Authors:

Yeleen Fromage

Hamza Sayadi

Marc Labriffe

Abstract

BACKGROUND: Maribavir is currently administered at a dose of 400 mg twice daily (q12h) for the treatment of cytomegalovirus (CMV) infections in transplant recipients. However, virological failure rates of up to 40% have been reported in clinical practice, with potentially severe consequences and the...

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