Beyond Circulating Tumor DNA for Efficacy: Can We Use Cell-Free DNA to Detect and Monitor Toxicity Signals?

Zhao, Yiqing; Gallon, John; H. Kushner, Max; Jakubison, Brad; S. Reis‐Filho, Jorge; Hodgson, Darren; Elvin, Julia; Dor, Yuval; Hadfield, James

doi:10.1200/po-26-00178

Public

Beyond Circulating Tumor DNA for Efficacy: Can We Use Cell-Free DNA to Detect and Monitor Toxicity Signals?

Published in JCO Precision Oncology • May 1, 2026

Authors:

Yiqing Zhao

John Gallon

Max H. Kushner

Abstract

Recent cell type methylome atlases revealed thousands of differentially methylated regions, 97% of which are unmethylated and typically overlap cell type-specific enhancers, as biomarkers that could be used to quantify cell-specific cfDNA.9,10 These developmentally linked loci appear to be universal...

Subject

Circulating tumor DNA

DNA

Cancer research

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