Computational stratification and engineering framework of the PDCD1/CD2 immune axis in triple-negative breast cancer

Abstract Purpose Triple-negative breast cancer (TNBC) is a high-risk molecular subtype defined by absence of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2) overexpression. Immune checkpoint blockade (ICB) benefits only 20% to 40% of patients, with T c... View More