Transient pores account for cell-penetrating peptide and homeoprotein translocation

Trofimenko, Evgeniya; Gervasi, Nicolas; Perez, Sylvie; Rodriguez, Nicolas; Ravault, Delphine; Cribier, Sophie; Berry, Hugues; Venance, Laurent; Sagan, Sandrine

doi:10.1073/pnas.2602649123

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Transient pores account for cell-penetrating peptide and homeoprotein translocation

Shared by NobleBlocks on Jun 22, 2026 • 12:00 AM UTC

Authors:

Evgeniya Trofimenko

Nicolas Gervasi

Sylvie Perez

Abstract

Homeoproteins (HPs) and cell-penetrating peptides (CPPs) enter cells by endocytosis and direct membrane crossing (translocation). However, unlike endocytosis, translocation remains globally unknown. Here, we developed an electrophysiological approach to assess the internalization of CPPs (Tat, R 9 ,...

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