A fully human streptolysin O-neutralizing monoclonal antibody improves survival in a murine model of group A streptococcus necrotizing soft tissue infection

Price, Emily; Nmaju, Anyauba; Faozia, Sabrina; L. Lamb, Cheri; R. McIndoo, Eric; Catlin, Sydney; Ayllon, Marcelo; Breuer, D; Sanders, Bryan; Fologea, Daniel; L Stevens, D; E. Bryant, Amy; E. Hobdey, Sarah

doi:10.1128/aac.00575-26

Public

A fully human streptolysin O-neutralizing monoclonal antibody improves survival in a murine model of group A streptococcus necrotizing soft tissue infection

Published in Antimicrobial Agents and Chemotherapy • Jul 17, 2026

Authors:

Emily Price

Anyauba Nmaju

Sabrina Faozia

Abstract

ABSTRACT Necrotizing soft tissue infections (NSTIs) caused by Streptococcus pyogenes (group A streptococcus [GAS]) are rapidly progressive, toxin-driven infections for which no targeted antitoxin therapies exist. Streptolysin O (SLO), a cholesterol-dependent cytolysin, is a key mediator of tissue in...

Subject

Streptolysin

Antitoxin

Streptococcus pyogenes

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