genenull: gene-identity null models for ClinVar benchmarks

A model scored only by the pathogenic fraction of a variant's own gene — no sequence, no structure, no conservation — reaches AUROC 0.921 on 197,904 ClinVar missense variants under a random 10-fold split, against 0.955–0.963 for four current predictors. Under within-gene evaluation the predictor ran... View More