Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

Tseng, J.; Dimitroff, K.; A. M. Sauder, C.; J. Chien, A.; A. Ahmed, K.; F. Allen, L.; A. Arciero, C.; E. Burke, E.; M. Chandler, J.; E. Jordan, J.; Golshan, M.; A. Gutnik, L.; T. Jaskowiak, N.; C. Hewitt, K.; Howard-McNatt, M.; Ito, F.; M. Kang, I.; B. Kesmodel, S.; M. Kuerer, H.; C. Lee, M.; S. Moran, M.; M. Postlewait, L.; D. Prionas, N.; Rao, R.; R. Reyna, C.; Schwer, A.; K. Taunk, N.; Tchou, J.; M. Wallace, A.; J. Li, T.; Perlmutter, J.; M. DeMichele, A.; Yee, D.; M. Hylton, N.; J. van’t Veer, L.; S. Rugo, H.; F. Symmans, W.; A. Shatsky, R.; J. D. Isaacs, C.; Yau, C.; J. Esserman, L.; C. Boughey, J.; A. Mukhtar, R.

doi:10.1245/s10434-026-20153-x

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Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

Shared by NobleBlocks on Aug 3, 2026 • 12:00 AM UTC

Authors:

J. Tseng

K. Dimitroff

C. A. M. Sauder

Abstract

Abstract Background Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST). This stud...

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