Smoking, but Not Malnutrition, Influences Promoter-Specific DNA Methylation of the Proopiomelanocortin Gene in Patients with and without Anorexia Nervosa

Ehrlich, Stefan; Walton, Esther; L. Roffman, Joshua; Weiss, Deike; Puls, Imke; Doehler, Nico; Burghardt, Roland; Lehmkuhl, Ulrike; Hillemacher, Thomas; Muschler, Marc; Frieling, Helge

doi:10.1177/070674371205700306

Public

Smoking, but Not Malnutrition, Influences Promoter-Specific DNA Methylation of the Proopiomelanocortin Gene in Patients with and without Anorexia Nervosa

Published in The Canadian Journal of Psychiatry • Mar 1, 2012

Authors:

Stefan Ehrlich

Esther Walton

Joshua L. Roffman

Abstract

OBJECTIVE: Our pilot study evaluates the impact of environmental factors, such as nutrition and smoking status, on epigenetic patterns in a disease-associated gene. METHOD: We measured the effects of malnutrition and cigarette smoking on proopiomelanocortin (POMC) promoter-specific DNA methylation i...

Subject

DNA methylation

Proopiomelanocortin

Epigenetics

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