Quantification of Human Uridine-Diphosphate Glucuronosyl Transferase 1A Isoforms in Liver, Intestine, and Kidney Using Nanobore Liquid Chromatography–Tandem Mass Spectrometry

E. Harbourt, David; K. Fallon, John; Ito, Shinya; Baba, Takashi; K. Ritter, Joseph; L. Glish, Gary; C. Smith, Philip

doi:10.1021/ac201704a

Public

Quantification of Human Uridine-Diphosphate Glucuronosyl Transferase 1A Isoforms in Liver, Intestine, and Kidney Using Nanobore Liquid Chromatography–Tandem Mass Spectrometry

Published in Analytical Chemistry • Nov 3, 2011

Authors:

David E. Harbourt

John K. Fallon

Shinya Ito

Abstract

Uridine-disphosphate glucuronosyl transferase (UGT) enzymes catalyze the formation of glucuronide conjugates of phase II metabolism. Methods for absolute quantification of UGT1A1 and UGT1A6 were previously established utilizing stable isotope peptide internal standards with liquid chromatography-tan...

Subject

Chemistry

Glucuronidation

Chromatography

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