Mechanically Regulated Cranial Growth in Infancy: 
A Computational Approach to Predicting 
Craniosynostosis

, Gary Testing; Vafaeefar1, Mahtab; Testing, Gary Testing; J. Vaughan1, Ted; Quinn1, Conall

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Mechanically Regulated Cranial Growth in Infancy: A Computational Approach to Predicting Craniosynostosis

Shared by Gary on Nov 1, 2025 • 12:41 AM UTC

Authors:

Mahtab Vafaeefar1

Ted J. Vaughan1

Conall Quinn1

Abstract

In early years of life, the cranium rapidly changes in size and shape to accommodate brain growth, primarily driven by mechanical stress from brain expansion. Developmental d isorders such as premature fusion of sutures in craniosynostosis, disrupt s normal growth process , leading to abnormal skull...

Subject

Cranial Growth

Craniosynostosis

Skull Development

Highlights

-Mechanically driven growth model coupling brain expansion with skull and sutural bone formation.

-Allows continuous, coupled simulation of intercranial volume growth and calvarial development over 12 months.

-Predicts craniosynostosis-associated dysmorphologies with agreement to clinical observations.

-Incorporates evolving tissue properties and bulk bone formation to capture long-term growth dynamics.

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