Histone H3K27ac separates active from poised enhancers and predicts developmental state.

P Creyghton, Menno; W Cheng, Albert; Grant Welstead, G; Kooistra, Tristan; W Carey, Bryce; J Steine, Eveline; Hanna, Jacob; A Lodato, Michael; M Frampton, Garrett; A Sharp, Phillip; A Boyer, Laurie; A Young, Richard; Jaenisch, Rudolf

doi:10.1073/pnas.1016071107

Public

Histone H3K27ac separates active from poised enhancers and predicts developmental state.

Published in Proceedings of the National Academy of Sciences of the United States of America • Dec 14, 2010

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Authors:

Menno P Creyghton

,

Albert W Cheng

,

G Grant Welstead

Abstract

Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers contribute to the specific gene expression programs that determine cell state ...

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