Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Published in Genome Biology • Mar 4, 2009
Authors:,,
Ben Langmead
Cole Trapnell
Mihai Pop
Abstract
Abstract Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of approximately 1.3 gigabytes. Bowtie ext...
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