Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Lieberman-Aiden, Erez; L. van Berkum, Nynke; Williams, Louise; Imakaev, Maxim; Ragoczy, Tobias; Telling, Agnes; Amit, Ido; R. Lajoie, Bryan; J. Sabo, Peter; O. Dorschner, Michael; Sandstrom, Richard; Bernstein, Bradley; A. Bender, M.; Groudine, Mark; Gnirke, Andreas; Stamatoyannopoulos, John; A. Mirny, Leonid; S. Lander, Eric; Dekker, Job

doi:10.1126/science.1181369

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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Published in Science • Oct 9, 2009

NobleIDark:/48914/w1/20260526/423F3358Record on NobleID

Authors:

Erez Lieberman-Aiden

,

Nynke L. van Berkum

,

Louise Williams

Abstract

Chromosomal Mapping The conformation of the genome in the nucleus and contacts between both proximal and distal loci influence gene expression. In order to map genomic contacts, Lieberman-Aiden et al. (p. 289 , see the cover) developed a technique to allow the detection of all interactions between g...

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