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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Published in Proceedings of the National Academy of Sciences • Sep 28, 2005
Authors:
Aravind Subramanian
,
Pablo Tamayo
,
Vamsi K. Mootha

Abstract

Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method called Gene Set Enrichment Analysis (GSEA) for interpreting gene expression data...

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