Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy.
Published in Biochemistry • Dec 2, 2008
Authors:,,
Ravi Prakash Reddy Nanga
Jeffrey R Brender
Jiadi Xu
Abstract
Disruption of the cellular membrane by the amyloidogenic peptide IAPP (or amylin) has been implicated in beta-cell death during type 2 diabetes. While the structure of the mostly inert fibrillar form of IAPP has been investigated, the structural details of the highly toxic prefibrillar membrane-boun...
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