Chuo University

The notion of viscosity solutions of scalar fully nonlinear partial differential equations of second order provides a framework in which startling comparison and uniqueness theorems, existence theorems, and theorems about continuous dependence may now be proved by very efficient and striking arguments. The range of important applications of these results is enormous. This article is a self-contained exposition of the basic theory of viscosity solutions.

BACKGROUND: Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear. METHODS: We randomly assigned 910 patients with HER2-negative residual invasive breast cancer after neoadjuvant chemotherapy (containing anthracycline, taxane, or both) to receive standard postsurgical treatment either with capecitabine or without (control). The primary end point was disease-free survival. Secondary end points included overall survival. RESULTS: The result of the prespecified interim analysis met the primary end point, so this trial was terminated early. The final analysis showed that disease-free survival was longer in the capecitabine group than in the control group (74.1% vs. 67.6% of the patients were alive and free from recurrence or second cancer at 5 years; hazard ratio for recurrence, second cancer, or death, 0.70; 95% confidence interval [CI], 0.53 to 0.92; P=0.01). Overall survival was longer in the capecitabine group than in the control group (89.2% vs. 83.6% of the patients were alive at 5 years; hazard ratio for death, 0.59; 95% CI, 0.39 to 0.90; P=0.01). Among patients with triple-negative disease, the rate of disease-free survival was 69.8% in the capecitabine group versus 56.1% in the control group (hazard ratio for recurrence, second cancer, or death, 0.58; 95% CI, 0.39 to 0.87), and the overall survival rate was 78.8% versus 70.3% (hazard ratio for death, 0.52; 95% CI, 0.30 to 0.90). The hand-foot syndrome, the most common adverse reaction to capecitabine, occurred in 73.4% of the patients in the capecitabine group. CONCLUSIONS: After standard neoadjuvant chemotherapy containing anthracycline, taxane, or both, the addition of adjuvant capecitabine therapy was safe and effective in prolonging disease-free survival and overall survival among patients with HER2-negative breast cancer who had residual invasive disease on pathological testing. (Funded by the Advanced Clinical Research Organization and the Japan Breast Cancer Research Group; CREATE-X UMIN Clinical Trials Registry number, UMIN000000843 .).

The XIS is an X-ray Imaging Spectrometer system, consisting of state-of-the-art charge-coupled devices (CCDs) optimized for X-ray detection, camera bodies, and control electronics. Four sets of XIS sensors are placed at the focal planes of the grazing-incidence, nested thin-foil mirrors (XRT: X-Ray Telescope) onboard the Suzaku satellite. Three of the XIS sensors have front-illuminated CCDs, while the other has a back-illuminated CCD. Coupled with the XRT, the energy range of 0.2–12 keV with energy resolution of 130 eV at 5.9 keV, and a field of view of $18^\prime \times 18^\prime$ are realized. Since the Suzaku launch on 2005 July 10, the XIS has been functioning well.

High-sensitivity wide-band X-ray spectroscopy is the key feature of the Suzaku X-ray observatory, launched on 2005 July 10. This paper summarizes the spacecraft, in-orbit performance, operations, and data processing that are related to observations. The scientific instruments, the high-throughput X-ray telescopes, X-ray CCD cameras, non-imaging hard X-ray detector are also described.

Recently, battery technology has come to require a higher rate capability. The main difficulty in high-rate charge-discharge experiments is kinetic problems due to the slow diffusion of Li-ions in electrodes. Nanosizing is a popular way to achieve a higher surface area and shorter Li-ion diffusion length for fast diffusion. However, while various nanoelectrodes that provide excellent high-rate capability have been synthesized, a size-controlled synthesis and a systematic study of nanocrystalline LiCoO2 have not been carried out because of the difficulty in controlling the size. We have established the size-controlled synthesis of nanocrystalline LiCoO2 through a hydrothermal reaction and, for the first time, clarified the structural and electrochemical properties of this intercalation cathode material. Lattice expansion in nanocrystalline LiCoO2 was found from powder X-ray diffraction measurements and Raman spectroscopy. Electrochemical measurements and theoretical analyses on nanocrystalline LiCoO2 revealed that extreme size reduction below 15 nm was not favorable for most applications. An excellent high-rate capability (65% of the 1 C rate capability at 100 C) was observed in nanocrystalline LiCoO2 with an appropriate particle size of 17 nm.

Much attention has been paid to the cross-coupling reaction of organosilicon compounds due to their stability, non-toxicity, and natural abundance of silicon. In addition, the silicon-based cross-coupling has many advantages over other cross-coupling protocols. Successful examples of the silicon-based cross-coupling reaction are reviewed, focusing especially on the advances made in the last decade. Having had a number of highly effective palladium catalysts developed mainly for other cross-coupling reactions, the development of the silicon-based protocol owes heavily to the design of organosilicon reagents which effectively undergo transmetalation, a key elemental step of the silicon-based cross-coupling reaction. This tutorial review thus classifies various organosilicon reagents depending on substituents on silicon and surveys their cross-coupling reactions with various electrophiles.

We present a measurement of the standard model $\mathrm{CP}$ violation parameter $\mathrm{sin}2{\ensuremath{\varphi}}_{1}$ based on a $29.1{\mathrm{fb}}^{\ensuremath{-}1}$ data sample collected at the $\ensuremath{\Upsilon}(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider. One neutral $B$ meson is fully reconstructed as a $J/\ensuremath{\psi}{K}_{S}$, $\ensuremath{\psi}(2S){K}_{S}$, ${\ensuremath{\chi}}_{c1}{K}_{S}$, ${\ensuremath{\eta}}_{c}{K}_{S}$, $J/\ensuremath{\psi}{K}_{L}$, or $J/\ensuremath{\psi}{K}^{*0}$ decay and the flavor of the accompanying $B$ meson is identified from its decay products. From the asymmetry in the distribution of the time intervals between the two $B$ meson decay points, we determine $\mathrm{sin}2{\ensuremath{\varphi}}_{1}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.99\ifmmode\pm\else\textpm\fi{}0.14(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}0.06(\mathrm{syst})$. We conclude that we have observed $\mathrm{CP}$ violation in the neutral $B$ meson system.

Staircase-like structures in the hysteresis loops at 0.04 K (see picture) are shown by doped single crystals of TBA[(Pc)2]− (Pc=phthalocyaninato, TBA=tetrabutylammonium), the first lanthanide single-molecule magnet. They are assigned to resonant quantum tunneling of magnetization between entangled states of the electron and nuclear spin systems. The Dy complex was also studied.

The first measurements of magnetization hysteresis loops on a diluted single crystal of [(Pc)2Ho]-.TBA+ (Pc = phthalocyaninato, TBA = tetrabutylammonium) in the subkelvin temperature range are reported. Characteristic staircase-like structure was observed, indicating the occurrence of the quantum tunneling of magnetization (QTM), which is a characteristic feature of SMMs. The quantum process in the new lanthanide SMMs is due to resonant quantum tunneling between entangled states of the electronic and nuclear spin systems, which is an essentially different mechanism from those of the known transition-metal-cluster SMMs. Evidence of the two-body quantum process was also observed for the first time in lanthanide complex systems.

The application of functional near-infrared spectroscopy (fNIRS) in the neurosciences has been expanding over the last 40 years. Today, it is addressing a wide range of applications within different populations and utilizes a great variety of experimental paradigms. With the rapid growth and the diversification of research methods, some inconsistencies are appearing in the way in which methods are presented, which can make the interpretation and replication of studies unnecessarily challenging. The Society for Functional Near-Infrared Spectroscopy has thus been motivated to organize a representative (but not exhaustive) group of leaders in the field to build a consensus on the best practices for describing the methods utilized in fNIRS studies. Our paper has been designed to provide guidelines to help enhance the reliability, repeatability, and traceability of reported fNIRS studies and encourage best practices throughout the community. A checklist is provided to guide authors in the preparation of their manuscripts and to assist reviewers when evaluating fNIRS papers.

There has been extensive research on the development of organic optoelectronic devices, such as organic light-emitting diodes, organic field-effect transistors, and organic solid-state lasers from various viewpoints, ranging from basic studies to practical applications. As organic materials are used as solids in these devices, the importance of organic chromophores that exhibit intense emissions of visible light in the solid state is greatly increasing in the field of organic electronics. However, highly efficient emission from organic solids is very difficult to attain because most organic emitting materials strongly tend to cause concentration quenching of the luminescence in the condensed phase. Therefore, in order to generate and improve organic optoelectronic devices, it is necessary to design novel chromophores that exhibit superior solid-state emission performance. This Focus Review covers the recent development of highly emissive organic small molecules whose photoluminescence quantum yields in the solid state have been reported. Following the introduction, the photophysical processes of excited molecules are briefly reviewed. Subsequently, organic solid fluorophores are described with an emphasis on the characteristics of their molecular structures.

Research Article| April 01, 1985 Response of alluvial rivers to slow active tectonic movement SHUNJI OUCHI SHUNJI OUCHI 1c/o Institute of Geosdences, Faculty of Science and Engineering, Chuo University, Kasuga, Bunkyo-ku, Tokyo 112, Japan Search for other works by this author on: GSW Google Scholar GSA Bulletin (1985) 96 (4): 504–515. https://doi.org/10.1130/0016-7606(1985)96<504:ROARTS>2.0.CO;2 Article history first online: 01 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation SHUNJI OUCHI; Response of alluvial rivers to slow active tectonic movement. GSA Bulletin 1985;; 96 (4): 504–515. doi: https://doi.org/10.1130/0016-7606(1985)96<504:ROARTS>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGSA Bulletin Search Advanced Search Abstract Alluvial rivers respond to valley-slope deformation caused by active tectonics in various ways depending on the rate and amount of surficial deformation and on the type of river. On the basis of experimental results and field examples, hypothetical models of river response to anticlinal uplift and synclinal subsidence were developed for different types of alluvial rivers.An experimental braided channel responded to anticlinal uplift across the channel with degradation and terrace formation in the central part of the uplift. With subsidence, aggradation in the central reach was the main response. Transverse bars developed downstream of the subsidence axis. An experimental meandering channel responded to slope steepening with a sinuosity increase. Bank erosion and point-bar growth occurred downstream of the anticlinal axis and upstream of the synclinal axis. Upstream of the uplift axis and downstream of the subsidence axis, where the slope was flattened, water flooded over bars.Local convexity in longitudinal profiles of the middle Rio Grande, New Mexico, is considered to be formed by a domal uplift. Local aggradation and degradation could be explained by the effect of uplift. The San Joaquin River, California, which is now highly controlled, does not show clear adjustment to the rapid subsidence due to ground-water withdrawal. It shows, however, a channel-pattern adjustment to active tectonic subsidence that has been occurring for a long time. The San Antonio and Guadalupe Rivers in Texas both increase their sinuosity significantly where monoclinal movements steepen valley slopes. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.

Organosilicon compounds act as a nucleophile upon activation by an appropriate base and behave in a manner similar to main-group organometallic reagents. In the last decades, structurally divergent organosilicon reagents are available and have become more employed for synthetic transformation with the aid of transition-metal complexes, because organosilicon compounds are in general superior to other organometallic compounds in view of stability, solubility, nontoxicity, and easy-handling. Particularly, cross-coupling of organosilicon reagents with organic halides or pseudohalides has been considered to be a useful tool for constructing the carbon frameworks of various target molecules such as pharmaceuticals and π-conjugated functional materials. Perfluoroalkylsilicon compounds such as CF3SiEt3 have found use as reagents for the metal-catalyzed introduction of perfluoroalkyl groups into many substrates. In addition, functionalized organosilicon reagents are readily accessible by catalytic approach starting with appropriate hydrocarbons such as alkenes, alkynes, alkanes, and arenes. This article reviews recent advances in transition-metal-catalyzed transformations of organosilicon reagents according to the type of synthetic transformation and metal catalyst.

Velocity field statistics in the inertial to dissipation range of three-dimensional homogeneous steady turbulent flow are studied using a high-resolution DNS with up to N=10243 grid points. The range of the Taylor microscale Reynolds number is between 38 and 460. Isotropy at the small scales of motion is well satisfied from half the integral scale (L) down to the Kolmogorov scale (η). The Kolmogorov constant is 1.64±0.04, which is close to experimentally determined values. The third order moment of the longitudinal velocity difference scales as the separation distance r, and its coefficient is close to 4/5. A clear inertial range is observed for moments of the velocity difference up to the tenth order, between 2λ≈100η and L/2≈300η, where λ is the Taylor microscale. The scaling exponents are measured directly from the structure functions; the transverse scaling exponents are smaller than the longitudinal exponents when the order is greater than four. The crossover length of the longitudinal velocity structure function increases with the order and approaches 2λ, while that of the transverse function remains approximately constant at λ. The crossover length and importance of the Taylor microscale are discussed.

(c) The Author(s) 2014. This article is published with open access at Springerlink.com.&#13;\nThis article is distributed under the terms of&#13;\nthe Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Funded by SCOAP3 / License Version CC BY 4.0.

Abstract Citizen science has a long history in the ecological sciences and has made substantial contributions to science, education, and society. Developments in information technology during the last few decades have created new opportunities for citizen science to engage ever larger audiences of volunteers to help address some of ecology's most pressing issues, such as global environmental change. Using online tools, volunteers can find projects that match their interests and learn the skills and protocols required to develop questions, collect data, submit data, and help process and analyze data online. Citizen science has become increasingly important for its ability to engage large numbers of volunteers to generate observations at scales or resolutions unattainable by individual researchers. As a coupled natural and human approach, citizen science can also help researchers access local knowledge and implement conservation projects that might be impossible otherwise. In Japan, however, the value of citizen science to science and society is still underappreciated. Here we present case studies of citizen science in Japan, the United States, and the United Kingdom, and describe how citizen science is used to tackle key questions in ecology and conservation, including spatial and macro‐ecology, management of threatened and invasive species, and monitoring of biodiversity. We also discuss the importance of data quality, volunteer recruitment, program evaluation, and the integration of science and human systems in citizen science projects. Finally, we outline some of the primary challenges facing citizen science and its future.

Functional near-infrared spectroscopy (fNIRS) is an optical imaging method that is used to noninvasively measure cerebral hemoglobin concentration changes induced by brain activation. Using structural guidance in fNIRS research enhances interpretation of results and facilitates making comparisons between studies. AtlasViewer is an open-source software package we have developed that incorporates multiple spatial registration tools to enable structural guidance in the interpretation of fNIRS studies. We introduce the reader to the layout of the AtlasViewer graphical user interface, the folder structure, and user files required in the creation of fNIRS probes containing sources and detectors registered to desired locations on the head, evaluating probe fabrication error and intersubject probe placement variability, and different procedures for estimating measurement sensitivity to different brain regions as well as image reconstruction performance. Further, we detail how AtlasViewer provides a generic head atlas for guiding interpretation of fNIRS results, but also permits users to provide subject-specific head anatomies to interpret their results. We anticipate that AtlasViewer will be a valuable tool in improving the anatomical interpretation of fNIRS studies.

There is a growing need for multicultural collaboration in child mental health services, training, and research. To facilitate such collaboration, this study tested the 8-syndrome structure of the Child Behavior Checklist (CBCL) in 30 societies. Parents' CBCL ratings of 58,051 6- to 18-year-olds were subjected to confirmatory factor analyses, which were conducted separately for each society. Societies represented Asia; Africa; Australia; the Caribbean; Eastern, Western, Southern, and Northern Europe; the Middle East; and North America. Fit indices strongly supported the correlated 8-syndrome structure in each of 30 societies. The results support use of the syndromes in diverse societies.

A photo-hydrogen-evolving molecular device made up of a tris(2,2'-bipyridine)ruthenium(II) derivative and a dichloro(2,2'-bipyridine)platinum(II) derivative has been found to serve as the first effective model of a "molecular device" which evolves molecular hydrogen from water in the presence of a sacrificial electron donor (EDTA), under the visible-light illumination.

On considere l'existence des solutions d'equations aux derivees partielles non lineaires scalaires d'ordre 1: F(x, u, Du)=0 dans Ω, ou Ω est un sous-ensemble ouvert de R N , F:Ω×R×R N →R est continue, u:Ω→R est l'inconnue