Délégation Ile-de-France Ouest et Nord

This dataset contains results from the comparison of optical clocks in Europe carried out in March 2023 using the European optical fiber network. The results are reported in Phys. Rev. Research 8, 033250 (2026). The involved optical clocks are: LNE-OP Hg optical lattice clock SYRTE-Hg, PTB Yb+(E2) ion clock PTB-Yb1E2, NPL Yb+(E3) ion clock NPL-E3Yb+3, PTB Yb+(E3) ion clock PTB-Yb1E3, INRIM Yb optical lattice clock IT-Yb1, NPL Sr optical lattice clock NPL-Sr1, PTB Sr optical lattice clock PTB-Sr3. Data is organized in folders, one for each comparison. Data is reported as fractional frequency ratios on a 1-s grid. The data follows the optical link data format developed for the EMPIR Projects OFTEN and ROCIT, and the European Partnership on Metrology Project TOCK. Timetags are reported in modified Julian date (MJD). A validity flag is given where 0 = invalid, valid otherwise. Each folder includes a yaml file with metadata required for generalized data processing. A Python package that can be used for data processing can be found on github. Inconsistencies have been observed in parts of the data; users should refer to the arXiv for details and interpretation.

Mass-radius posterior samples and contours for the headline result from the analysis of the millisecond pulsar PSR J1614−2230 presented in "A NICER view of PSR J1614−2230: a massive and compact millisecond pulsar" (Mauviard et al. 2026) The full reproduction package will be made available upon acceptance of the manuscript.

Mass-radius posterior samples and contours for the headline result from the analysis of the millisecond pulsar PSR J1614−2230 presented in "A NICER view of PSR J1614−2230: a massive and compact millisecond pulsar" (Mauviard et al. 2026) The full reproduction package will be made available upon acceptance of the manuscript.

A model scored only by the pathogenic fraction of a variant's own gene — no sequence, no structure, no conservation — reaches AUROC 0.921 on 197,904 ClinVar missense variants under a random 10-fold split, against 0.955–0.963 for four current predictors. Under within-gene evaluation the predictor ranking inverts, and across 22 dbNSFP predictors roughly half the advantage conventional benchmarks give clinically supervised models is gene identity rather than variant-level discrimination. Contains the genenull module, the analysis pipeline, the figure scripts, the pre-registered predictor exposure classification, and every result table the manuscript reports.

A model scored only by the pathogenic fraction of a variant's own gene — no sequence, no structure, no conservation — reaches AUROC 0.921 on 197,904 ClinVar missense variants under a random 10-fold split, against 0.955–0.963 for four current predictors. Under within-gene evaluation the predictor ranking inverts, and across 22 dbNSFP predictors roughly half the advantage conventional benchmarks give clinically supervised models is gene identity rather than variant-level discrimination. Contains the genenull module, the analysis pipeline, the figure scripts, the pre-registered predictor exposure classification, and every result table the manuscript reports.

Don file for CESAM model

Don file for CESAM model

Gallium oxide (Ga2O3) is an emerging ultrawide-bandgap semiconductor for next-generation power electronics. However, the relatively low thermal conductivity of the technologically most promising β-Ga2O3 phase poses a major challenge for thermal management in high-power devices. The metastable corundum α-Ga2O3 phase is predicted to exhibit higher thermal conductivity and offers good lattice compatibility with sapphire substrates, making it a promising alternative for improved heat dissipation. In this work, α-Ga2O3 thin films were heteroepitaxially grown on m-plane sapphire substrates by reactive pulsed-DC magnetron sputtering from a liquid gallium target [1-2]. A 207 nm thick α-Ga2O3 film was investigated and compared with two β-Ga2O3 samples: a 500 nm heteroepitaxial film on sapphire grown by metalorganic chemical vapour deposition [3] and a commercial β-Ga2O3 epilayer. Structural properties were examined by X-ray diffraction and Raman spectroscopy, while thermal conductivity was measured using time-domain thermoreflectance (TDTR). The α-Ga2O3/sapphire heterostructure exhibited the highest thermal conductivity of 22 ± 2 W·m⁻¹·K⁻¹ at room temperature, significantly exceeding the value obtained for the 500 nm β-Ga2O3 film on sapphire (3.7 ± 0.2 W·m⁻¹·K⁻¹) and also surpassing the β-Ga2O3 epilayer (9.3 ± 0.3 W·m⁻¹·K⁻¹). These results demonstrate the potential of heteroepitaxially stabilized α-Ga2O3 thin films on sapphire as a promising platform for improved thermal management in Ga2O3-based power devices. [1] E. Butanovs, M. Zubkins, E. Strods, V. Vibornijs, K. Kadiwala, L. Ignatane, B. Polyakov, S. Vlassov, J. Purans. Impact of temperature and film thickness on α- and β- phase formation in Ga2O3 thin films grown on a-plane sapphire substrate. Thin Solid Films 803, 140467 (2024) [2] M. Zubkins, V. Vibornijs, E. Strods, E. Butanovs, L. Bikse, M. Ottosson, A. Hallen, J. Gabrusenoks, J. Purans, A. Azens. Deposition of Ga2O3 thin films by liquid metal target sputtering. Vacuum 209, 111789 (2023)

Gallium oxide (Ga2O3) is an emerging ultrawide-bandgap semiconductor for next-generation power electronics. However, the relatively low thermal conductivity of the technologically most promising β-Ga2O3 phase poses a major challenge for thermal management in high-power devices. The metastable corundum α-Ga2O3 phase is predicted to exhibit higher thermal conductivity and offers good lattice compatibility with sapphire substrates, making it a promising alternative for improved heat dissipation. In this work, α-Ga2O3 thin films were heteroepitaxially grown on m-plane sapphire substrates by reactive pulsed-DC magnetron sputtering from a liquid gallium target [1-2]. A 207 nm thick α-Ga2O3 film was investigated and compared with two β-Ga2O3 samples: a 500 nm heteroepitaxial film on sapphire grown by metalorganic chemical vapour deposition [3] and a commercial β-Ga2O3 epilayer. Structural properties were examined by X-ray diffraction and Raman spectroscopy, while thermal conductivity was measured using time-domain thermoreflectance (TDTR). The α-Ga2O3/sapphire heterostructure exhibited the highest thermal conductivity of 22 ± 2 W·m⁻¹·K⁻¹ at room temperature, significantly exceeding the value obtained for the 500 nm β-Ga2O3 film on sapphire (3.7 ± 0.2 W·m⁻¹·K⁻¹) and also surpassing the β-Ga2O3 epilayer (9.3 ± 0.3 W·m⁻¹·K⁻¹). These results demonstrate the potential of heteroepitaxially stabilized α-Ga2O3 thin films on sapphire as a promising platform for improved thermal management in Ga2O3-based power devices. [1] E. Butanovs, M. Zubkins, E. Strods, V. Vibornijs, K. Kadiwala, L. Ignatane, B. Polyakov, S. Vlassov, J. Purans. Impact of temperature and film thickness on α- and β- phase formation in Ga2O3 thin films grown on a-plane sapphire substrate. Thin Solid Films 803, 140467 (2024) [2] M. Zubkins, V. Vibornijs, E. Strods, E. Butanovs, L. Bikse, M. Ottosson, A. Hallen, J. Gabrusenoks, J. Purans, A. Azens. Deposition of Ga2O3 thin films by liquid metal target sputtering. Vacuum 209, 111789 (2023)

Introduction: Transgender women are disproportionately affected by HIV worldwide, yet data on engagement in HIV care and treatment outcomes remain limited and inconsistent, particularly in European healthcare settings. We aimed to compare retention in care and virological outcomes among transgender women and cisgender people living with HIV. Methods: We conducted a retrospective cohort study using routinely collected clinical data from two tertiary hospitals in Paris, France. Adults living with HIV who initiated care between 2008 and 2018 were included and classified as transgender women, cisgender men or cisgender women. Loss to follow-up was defined as the absence of any clinical visit for a continuous 24-month period. Virological response was defined as the time to first HIV viral load <50 copies/mL. Patients with an undetectable viral load at entry into care were excluded from time-to-event analyses. Kaplan-Meier methods and Cox proportional hazards models were used to compare outcomes between groups. Results: A total of 129 transgender women, 1304 cisgender men and 523 cisgender women were included. The majority of transgender women (93.4%) were migrants from Latin America and their mean age at entry into care was lower than that of cisgender patients. After multivariable adjustment, no significant difference in loss to follow-up was observed between transgender women and cisgender men (aHR=1.06, 95% CI 0.72 to 1.63) or cisgender women (aHR=1.07, 95% CI 0.66 to 1.74). Time to virological response did not differ significantly between transgender women and cisgender men (aHR=1.04, 95% CI 0.85 to 1.30) or cisgender women (aHR=1.24, 95% CI 0.98 to 1.60) after adjustment. Conclusions: In this cohort from two Parisian hospitals, transgender women demonstrated retention in care and virological outcomes comparable to those of cisgender people living with HIV. These findings suggest that within supportive healthcare settings, HIV care outcomes among transgender women can be similar to those observed in cisgender populations.

This is a basic reproduction package for the paper "Direct Imaging Discovery of Giant Exoplanet β Pictoris d: A Decade-Long Game of Hide-and-Seek" by Sutlieff & Bonse et al. (2026). The data and relevant calibrations from the observations underlying this article will be included in upcoming versions of this reproduction package to be released after the final publication of the paper. This is the original, empty version of this package; please check the versions panel for more recent releases.

This is a basic reproduction package for the paper "Direct Imaging Discovery of Giant Exoplanet β Pictoris d: A Decade-Long Game of Hide-and-Seek" by Sutlieff & Bonse et al. (2026). The data and relevant calibrations from the observations underlying this article will be included in upcoming versions of this reproduction package to be released after the final publication of the paper. This is the original, empty version of this package; please check the versions panel for more recent releases.

While the dynamic changes in genome organization in cellular organisms have been well described, the 3D folding of phage genomes during the infection of their host is extremely limited. Understanding how phage genomes fold, invade and rearrange the genome of their host to functionally organize the optimal expression of their genes remains unknown. Here, we explore the spatial dynamics of the virulent double-stranded DNA phage PAK_P3 during infection of its host Pseudomonas aeruginosa and reveal how its genome rapidly decondenses to adopt a specific 3D organization that reflects its transcriptional program. Concomitantly, the host genome decondenses as gene expression wanes and transcription induced domains vanish. We also uncover specific contacts of the phage genome with host chromosome, showing how the phage genome exploits the spatial genome architecture of its host to succeed in its infection cycle. Our data highlights an unprecedented level of genome folding and gene expression regulation during a viral infection.

While the dynamic changes in genome organization in cellular organisms have been well described, the 3D folding of phage genomes during the infection of their host is extremely limited. Understanding how phage genomes fold, invade and rearrange the genome of their host to functionally organize the optimal expression of their genes remains unknown. Here, we explore the spatial dynamics of the virulent double-stranded DNA phage PAK_P3 during infection of its host Pseudomonas aeruginosa and reveal how its genome rapidly decondenses to adopt a specific 3D organization that reflects its transcriptional program. Concomitantly, the host genome decondenses as gene expression wanes and transcription induced domains vanish. We also uncover specific contacts of the phage genome with host chromosome, showing how the phage genome exploits the spatial genome architecture of its host to succeed in its infection cycle. Our data highlights an unprecedented level of genome folding and gene expression regulation during a viral infection.

For a whole week, amidst the fabulous scenery of the Dolomites of Sexten (Italy), we enjoyed stimulating presentations and lively discussions on observations and theoretical interpretations of the abundances of CNOPS elements. We believe this was a very fruitful week, and in this collection of contributions, we have sought to capture the key topics covered during the workshop.

For a whole week, amidst the fabulous scenery of the Dolomites of Sexten (Italy), we enjoyed stimulating presentations and lively discussions on observations and theoretical interpretations of the abundances of CNOPS elements. We believe this was a very fruitful week, and in this collection of contributions, we have sought to capture the key topics covered during the workshop.

In this contribution we investigate the CNO abundances in five apparently young evolved stars, with the aim of discriminating between truly young stars and stars that were rejuvenated by accreting mass from another star. Stars that have accreted mass are expected to show low C and O and a very low [C/O] ratio, as displayed by some stars in the Globular Cluster 47 Tuc, that are believed to have undergone mass-transfer. In our sample the low [C/O] ratios observed appear to be compatible with their evolutionary status. There is thus no indication for these stars having accreted mass.

In this contribution we investigate the CNO abundances in five apparently young evolved stars, with the aim of discriminating between truly young stars and stars that were rejuvenated by accreting mass from another star. Stars that have accreted mass are expected to show low C and O and a very low [C/O] ratio, as displayed by some stars in the Globular Cluster 47 Tuc, that are believed to have undergone mass-transfer. In our sample the low [C/O] ratios observed appear to be compatible with their evolutionary status. There is thus no indication for these stars having accreted mass.

There are three folders for our code: Code expe N1, Code expe N2 and Code expe A. Each folder contains the code to generate all our results and the databases they use.

bAIes and coil ensembles from "Atomic resolution ensembles of intrinsically disordered proteins with Alphafold".