Centre d’Economie Industrielle - CERNA

Horizontal collaboration has been considered as effective practice for sustainable logistics and freight transport and it has gained increased attention in recent years. This paper aims to provide a survey of the development of horizontal collaborative transport (HCT) over the past ten years, to identify research trends and gaps, then to propose some research opportunities. The paper also aims to provide guidelines to logistics companies who wish to embark on HCT, to help them choose which HCT solution to implement. To provide a comprehensive and structured review, the paper follows the methodology for Systematic Literature Review proposed in the literature. A total of 120 scientific papers published between 2007 and 2017 were reviewed. A survey framework based on two axes – HCT solutions and implementation issues – is developed to analyse and position the papers. The results show that, regarding HCT solutions, carrier alliance and flow controller collaboration were the most frequently studied. But recent innovative solutions such as pooling and physical internet are also gaining increased attention. Regarding implementation issues, the focus of the literature has been on the development of decision-making models, including transport planning, lane exchange, and gain sharing. Conversely, managerial and technological issues have received less attention.

The vasculitis of Behçet disease (BD) is distinctive because of involvement of both arteries and veins of all sizes. The concept of vasculo-Behçet disease has been adopted for cases in which vascular manifestations are present and often dominate the clinical features. While venous manifestations are frequent and have been reported in many publications, data regarding arterial lesions in patients with BD are rare and often isolated. In this study, we report the main characteristics, treatment, and long-term outcome of 101 patients with arterial lesions among a cohort of 820 (12.3%) BD patients. Factors that affect prognosis were assessed by multivariate analysis. There were 93 (91.2%) male patients; the median (Q1-Q3) age at diagnosis of BD was 33 (27-41) years. Arterial lesions included aneurysms (47.3%), occlusions (36.5%), stenosis (13.5%), and aortitis (2.7%). Lesions mainly involved the aorta (n = 25) and femoral (n = 23) and pulmonary (n = 21) arteries. Patients with arterial lesions were more frequently male (91.2% vs. 62.4%, respectively; p = 0.017) and had higher rates of venous involvement (80.4% vs. 29.8%, respectively; p < 0.001) compared to patients without arterial manifestations. Thirty-nine (38.6%) patients achieved complete remission. In multivariate analysis, the presence of venous involvement (odds ratio [OR], 0.29; 95% confidence interval [CI], 0.08-1.11) and arterial occlusive lesions (OR, 0.13; 95% CI, 0.01-1.25) were negatively associated with complete remission. The use of immunosuppressants (OR, 3.38; 95% CI, 0.87-13.23) was associated with the occurrence of complete remission. The 20-year survival rate was significantly lower in BD patients with arterial involvement than in those without arterial lesions (73% vs. 89%, respectively; p < 0.0001). In conclusion, the long-term outcome of arterial lesions in BD is poor, especially in the case of occlusive lesions and associated venous involvement. The use of immunosuppressants improved the prognosis.

In addition to CD4(+) regulatory T cells (Tregs), CD8(+) suppressor T cells are emerging as an important subset of regulatory T cells. Diverse populations of CD8(+) T cells with suppressive activities have been described. Among them, a small population of CD8(+)CD25(+)FOXP3(+) T cells is found both in mice and humans. In contrast to thymic-derived CD4(+)CD25(+)FOXP3(+) Tregs, their origin and their role in the pathophysiology of autoimmune diseases (AIDs) are less understood. We report here the number, phenotype, and function of CD8(+) Tregs cells in mice and humans, at the steady state and in response to low-dose interleukin-2 (IL-2). CD8(+) Tregs represent approximately 0.4 and 0.1% of peripheral blood T cells in healthy humans and mice, respectively. In mice, their frequencies are quite similar in lymph nodes (LNs) and the spleen, but two to threefold higher in Peyer patches and mesenteric LNs. CD8(+) Tregs express low levels of CD127. CD8(+) Tregs express more activation or proliferation markers such as CTLA-4, ICOS, and Ki-67 than other CD8(+) T cells. In vitro, they suppress effector T cell proliferation as well as or even better than CD4(+) Tregs. Owing to constitutive expression of CD25, CD8(+) Tregs are 20- to 40-fold more sensitive to in vitro IL-2 stimulation than CD8(+) effector T cells, but 2-4 times less than CD4(+) Tregs. Nevertheless, low-dose IL-2 dramatically expands and activates CD8(+) Tregs even more than CD4(+) Tregs, in mice and humans. Further studies are warranted to fully appreciate the clinical relevance of CD8(+) Tregs in AIDs and the efficacy of IL-2 treatment.

A fixation on 'scaling up' has captured current innovation discourses and, with it, political and economic life at large. Perhaps most visible in the rise of platform technologies, big data and concerns about a new era of monopolies, scalability thinking has also permeated public policy in the search for solutions to 'grand societal challenges', 'mission-oriented innovation' or transformations through experimental 'living labs'. In this paper, we explore this scalability zeitgeist as a key ordering logic of current initiatives in innovation and public policy. We are interested in how the explicit preoccupation with scalability reconfigures political and economic power by invading problem diagnoses and normative understandings of how society and social change function. The paper explores three empirical sites - platform technologies, living labs and experimental development economics - to analyze how scalability thinking is rationalized and operationalized. We suggest that social analysis of science and technology needs to come to terms with the 'politics of scaling' as a powerful corollary of the 'politics of technology', lest we accept the permanent absence from key sites where decisions about the future are made. We focus in on three constitutive elements of the politics of scaling: solutionism, experimentalism and future-oriented valuation. Our analysis seeks to expand our vocabulary for understanding and questioning current modes of innovation that increasingly value scaling as an end in itself, and to open up new spaces for alternative trajectories of social transformation.

T and B cell repertoires are collections of lymphocytes, each characterized by its antigen-specific receptor. We review here classical technologies and analysis strategies developed to assess immunoglobulin (IG) and T cell receptor (TR) repertoire diversity, and describe recent advances in the field. First, we describe the broad range of available methodological tools developed in the past decades, each of which answering different questions and showing complementarity for progressive identification of the level of repertoire alterations: global overview of the diversity by flow cytometry, IG repertoire descriptions at the protein level for the identification of IG reactivities, IG/TR CDR3 spectratyping strategies, and related molecular quantification or dynamics of T/B cell differentiation. Additionally, we introduce the recent technological advances in molecular biology tools allowing deeper analysis of IG/TR diversity by next-generation sequencing (NGS), offering systematic and comprehensive sequencing of IG/TR transcripts in a short amount of time. NGS provides several angles of analysis such as clonotype frequency, CDR3 diversity, CDR3 sequence analysis, V allele identification with a quantitative dimension, therefore requiring high-throughput analysis tools development. In this line, we discuss the recent efforts made for nomenclature standardization and ontology development. We then present the variety of available statistical analysis and modeling approaches developed with regards to the various levels of diversity analysis, and reveal the increasing sophistication of those modeling approaches. To conclude, we provide some examples of recent mathematical modeling strategies and perspectives that illustrate the active rise of a "next-generation" of repertoire analysis.

Abstract This chapter focuses on the role of digital intermediaries in shaping technology, society, and economy under what Casilli and Posada call “the paradigm of the platform.” They trace the historical relationship between platforms, markets, and enterprises to demonstrate the role of algorithms in matching users, pieces of software, goods, and services, and how platforms can create value from the content and data generated by users. Their primary argument is that platforms play a fundamental role in establishing a digital labor relationship with their users by allocating underpaid or unpaid tasks to them. In order to enable and coordinate users’ contributions, platforms need to standardize and fragment (“taskify”) labor processes. The authors conclude by highlighting the link between platformization and automation, with the tech giants employing their users’ data to produce artificial intelligence and machine-learning solutions to an expanding range of problems.

Chronic hepatitis C virus (HCV) infection, with its cohort of life-threatening complications, affects more than 200 million persons worldwide and has a prevalence of more than 10% in certain countries. Preventive and therapeutic vaccines against HCV are thus much needed. Neutralizing antibodies (NAbs) are the foundation for successful disease prevention for most established vaccines. However, for viruses that cause chronic infection such as HIV or HCV, induction of broad NAbs from recombinant vaccines has remained elusive. We developed a vaccine platform specifically aimed at inducing NAbs based on pseudotyped virus-like particles (VLPs) made with retroviral Gag. We report that VLPs pseudotyped with E2 and/or E1 HCV envelope glycoproteins induced high-titer anti-E2 and/or anti-E1 antibodies, as well as NAbs, in both mouse and macaque. The NAbs, which were raised against HCV 1a, cross-neutralized the five other genotypes tested (1b, 2a, 2b, 4, and 5). Thus, the described VLP platform, which can be pseudotyped with a vast array of virus envelope glycoproteins, represents a new approach to viral vaccine development.

OBJECTIVES: The recent emergence of Zika in Brazil and its association with an increased rate of congenital malformations has raised concerns over its impact on the birth rate in the country. Using data on the incidence of Zika in 2015-2016 and dengue in 2013 and 2015-2016 for the city of Rio de Janeiro (population 6.4 million), a massive increase of Zika in women compared to men was documented. METHODS: The age-adjusted incidence was compared between men and women. A negative binomial Poisson generalized linear model was fitted to the Zika incidence data to determine the significance of sexual transmission statistically. RESULTS: Even after correcting for the bias due to the systematic testing of pregnant women for Zika, there were found to be 90% more registered cases per 100000 women than men in the sexually active age group (15-65 years); this was not the case for age groups <15 years and >65 years. Assuming that infected men transmit the disease to women in their semen, but that the converse is not true, some extra incidence in women is to be expected. An alternate hypothesis would be that women visit doctors more often than men. To test this, the incidence of dengue fever was compared in men and women in 2015 and in 2013 (before Zika reached Rio de Janeiro): in both years, women were 30% more likely to be reported with dengue. CONCLUSION: Women in the sexually active age group are far more likely to get Zika than men (+90% increase); sexual transmission is the most probable cause. Women in the 15-65 years age group are also 30% more likely to be reported with dengue than men, which is probably due to women being more careful with their health.

New pedagogical visions and technological developments have brought argumentation to the fore of educational practice. Whereas students previously &amp;apos;learned to &amp;apos;argue&amp;apos;, they now &amp;apos;argue to learn&amp;apos;: collaborative argumentation-based learning has become a popular and valuable pedagogical technique, across a variety of tasks and disciplines. Researchers have explored the conditions under which arguing to learn is successful, have described some of its learning potentials (such as for conceptual change and reflexive learning) and have developed Internet-based tools to support such learning. However, the further advancement of this field presently faces several problems, which the present book addresses. Three dimensions of analysis - historical, theoretical and empirical - are integrated throughout the book. Given the nature of its object of study - dialogue, interaction, argumentation, learning and teaching - the book is resolutely multidisciplinary, drawing on research on learning in educational and psychological sciences, as well as on philosophical and linguistic theories of dialogue and argumentation.

International audience

International audience

This paper provides an in-depth analysis of the characteristics of international patent families, including their domestic component. We exploit a relatively under-studied feature of patent families, namely the number of patents covering the same invention within a given jurisdiction. Using this information, we highlight common patterns in the structure of international patent families, which reflect both the patenting strategies of innovators and the peculiarities of the different patent systems. While the literature has extensively used family size, i.e. the number of countries in which a given invention is protected, as a measure of patent value, our results suggest that the number of patent filings in the priority country within a patent family as well as the timespan between the first and last filings within a family are other insightful indicators of the value of patented innovations.

Based on a study of a network of fab labs and makerspaces, this article investigates the role that such ‘fabrication spaces’ can play in fostering 21st century skills. Using a combination of the two main 21st century skills frameworks—DigComp and EntreComp—developed by the EU Commission, we study by the means of two combined qualitative research methods—semi-structured interviews of 13 fab lab/makerspace founders, followed by a focus group with founders and policymaker—the entrepreneurial and digital skills that are fostered by these fab labs and makerspaces. Our findings are that while fab labs and makerspaces naturally foster some entrepreneurial 21st century skills, only explicit and proactive entrepreneurship and education programme enable to foster the whole spectrum of these skills. In regard to technical skills, fab labs and makerspaces enable to develop skills beyond what is generally considered as 21st century digital skills, because they combine digital skills with hands-on ‘making’ skills, since they are themselves mixed environment, both digital and physical. Consequently, the growing importance of ‘maker technologies’ may force to redefine what 21st century skills should be.

In this book, a number of experts from various disciplines take a look at three different strands in learning to model. They examine the activity of modeling from disparate theoretical standpoints, taking into account the individual situation of the individuals involved. The chapters seek to bridge the modeling of communication and the modeling of particular scientific domains. In so doing, they seek to throw light on the educational communication that goes on in conceptual learning. Taken together, the chapters brought together in this volume illustrate the diversity and vivacity of research on a relatively neglected, yet crucially important aspect of education across disciplines: learning to model. A common thread across the research presented is the view that communication and interaction, as fundamental to most educational practices and as a repository of conceptual understanding and a learning mechanism in itself, is intimately linked to elaborating meaningful, coherent, and valid representations of the world. The editors hope this volume will contribute to both the fundamental research in its field and ultimately provide results that can be of practical value in designing new situations for teaching and learning modeling, particularly those involving computers.

The popularity of round-the-clock online shopping urges the rapid growth of e-commerce, which substantially generates additional parcels for the distribution on the forward side. On the other hand, collecting the returned goods on the revere side is also increasingly becoming a preoccupation, particularly in the crowd and dense metropolitan areas. Inspired by the concepts of Crowdsourcing and Physical Internet, we propose an innovative solution to collect the e-commerce returned goods from final consumption points back to retailers. As an alternative to traditional ways, this solution delivers the returned goods and passengers in an integrated way by leveraging the extra loading capacity and constant mobility provided by taxis that are already reserved to transport passengers. Thus, it could simultaneously migrate the negative economical, environmental and social impacts of reverse flows management. To address the issue of the returned goods collection, we first conduct the qualitative and quantitative study, and further investigate the feasibility and viability of the solution based on three real-world datasets, which consist of locations of shops, a road network and a large-scale trajectory data generated by over 7000 taxis in a month in the city of Hangzhou, China. Three collection strategies are proposed and evaluated. Experimental results generate several useful insights into the implementability and managerial issues of the proposed solution.

Abstract Contributorship statements were introduced by scholarly journals in the late 1990s to provide more details on the specific contributions made by authors to research papers. After more than a decade of idiosyncratic taxonomies by journals, a partnership between medical journals and standards organizations has led to the establishment, in 2015, of the Contributor Roles Taxonomy (CRediT), which provides a standardized set of 14 research contributions. Using the data from Public Library of Science (PLOS) journals over the 2017–2018 period (N = 30,054 papers), this paper analyzes how research contributions are divided across research teams, focusing on the association between division of labor and number of authors, and authors’ position and specific contributions. It also assesses whether some contributions are more likely to be performed in conjunction with others and examines how the new taxonomy provides greater insight into the gendered nature of labor division. The paper concludes with a discussion of results with respect to current issues in research evaluation, science policy, and responsible research practices.

International audience

Résumé L’activité renvoie généralement à ce qui est mis en œuvre par des personnes pour accomplir leurs tâches dans des contextes de travail ou dans le cadre d’usages d’objets techniques du quotidien. Depuis quelques années, on note un intérêt croissant pour la notion d’expérience subjective, particulièrement dans le domaine de l’interaction Homme-Machine. En ergonomie et en psychologie de l’activité, cet intérêt a produit des approches théoriques et méthodologiques variées de l’expérience subjective. La relation entre l’expérience subjective et l’activité a cependant été peu étudiée à ce jour. Les liens entre ces concepts sont plus ou moins clairs, et la notion d’expérience subjective est souvent mal comprise. Une des contributions de cet article est de clarifier les liens entre l’expérience vécue, caractérisée selon une approche phénoménologique, et l’activité. Dans cette perspective, l’expérience vécue d’une activité est définie comme le flux d’actions, émotions, pensées et sensations perceptives qui émergent dans le cours de l’activité et dont le sujet est, ou peut être rendu réflexivement conscient. A partir de cette définition, sont examinées les méthodes qui nous paraissent les plus pertinentes pour documenter l’expérience vécue (autoconfrontation et entretien d’explicitation) et l’on montre comment l’analyse détaillée de celle-ci nous renseigne de façon significative pour la compréhension de l’activité.

BACKGROUND: Behcet's disease (BD) is a well-known cause of Budd-Chiari syndrome (BCS). Data are lacking on the presentation and outcome of BCS related to BD. METHODS: We investigated the relationship between BD and BCS in 14 patients with both diseases and compared the results to 92 BCS patients without BD. RESULTS: Male gender (p = 0.003), North African origin (P = 0.007) and inferior vena cava obstruction (P < 0.0001) were more frequent in patients with BD and BCS than in those with BCS alone and the plasma C-reactive protein level was higher (p = 0.003). Two of the patients with the combined diseases underwent recanalization of the vena cava and the hepatic veins, none received transjugular intrahepatic portosystemic shunts (TIPS), one received a surgical shunt and one underwent liver transplantation. TIPS were less frequent in patients with BD and BCS than in those with BCS alone (P = 0.019). Eighty six per cent of patients with BCS and BD received corticosteroids and immunosuppressive therapy. The 5-year transplantation-free survival rate was 63% in patients with BCS alone and 91% in those without BD (P = 0.11). In our series and in the literature, a high number of patients [12 (61.5%) and 11 (64.7%) respectively] treated with anticoagulation and corticosteroids and/or immunosuppressants did not require invasive treatment. CONCLUSION: This study shows a higher frequency of IVC obstruction in patients with BCS and BD. Medical treatment with anticoagulation and immunosuppressive agents may improve the symptoms of BCS. Therefore early management with immunosuppressive and anticoagulation therapy appears to be the treatment of choice in patients with BCS and BD.

Abstract Due to pressing sustainability challenges, the fashion industry is undergoing tremendous change. Surprisingly, even though the unique context of fashion presents an opportunity for scholars to explore the (un)sustainable transitions, this context has yet to receive the attention of transition scholars. Our article explores fashion transitions and develops a conceptual framework demonstrating this transition's multi-level and multi-dimensional interactions. We draw on three literature areas: multi-level perspective (MLP) of sustainable transitions, institutional logics and framing contests. We then introduce a conceptual framework and illustrative examples from the industry and demonstrate the tensions between positive and negative environmental and social sustainability developments at the niche, regime and landscape levels. We show that while many positive developments can be seen in the regime players through the adoption of corporate sustainability initiatives, new business models and collaborations, more attention should also be given to some adverse developments. Overall, we contribute to the literature by exploring fashion transitions, an under-explored context, and by demonstrating the complexity of interactions due to the diffusion of heterogeneous institutional logics and framing contests between players.