Université Sorbonne Nouvelle

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Accurate assessment of anthropogenic carbon dioxide (CO 2 ) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate is critical to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe and synthesize data sets and methodologies to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO 2 emissions ( E FOS ) are based on energy statistics and cement production data, while emissions from land-use change ( E LUC ), mainly deforestation, are based on land use and land-use change data and bookkeeping models. Atmospheric CO 2 concentration is measured directly, and its growth rate ( G ATM ) is computed from the annual changes in concentration. The ocean CO 2 sink ( S OCEAN ) is estimated with global ocean biogeochemistry models and observation-based data products. The terrestrial CO 2 sink ( S LAND ) is estimated with dynamic global vegetation models. The resulting carbon budget imbalance ( B IM ), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and understanding of the contemporary carbon cycle. All uncertainties are reported as ±1 σ . For the year 2021, E FOS increased by 5.1 % relative to 2020, with fossil emissions at 10.1 ± 0.5 GtC yr −1 (9.9 ± 0.5 GtC yr −1 when the cement carbonation sink is included), and E LUC was 1.1 ± 0.7 GtC yr −1 , for a total anthropogenic CO 2 emission (including the cement carbonation sink) of 10.9 ± 0.8 GtC yr −1 (40.0 ± 2.9 GtCO 2 ). Also, for 2021, G ATM was 5.2 ± 0.2 GtC yr −1 (2.5 ± 0.1 ppm yr −1 ), S OCEAN was 2.9 ± 0.4 GtC yr −1 , and S LAND was 3.5 ± 0.9 GtC yr −1 , with a B IM of −0.6 GtC yr −1 (i.e. the total estimated sources were too low or sinks were too high). The global atmospheric CO 2 concentration averaged over 2021 reached 414.71 ± 0.1 ppm. Preliminary data for 2022 suggest an increase in E FOS relative to 2021 of +1.0 % (0.1 % to 1.9 %) globally and atmospheric CO 2 concentration reaching 417.2 ppm, more than 50 % above pre-industrial levels (around 278 ppm). Overall, the mean and trend in the components of the global carbon budget are consistently estimated over the period 1959–2021, but discrepancies of up to 1 GtC yr −1 persist for the representation of annual to semi-decadal variability in CO 2 fluxes. Comparison of estimates from multiple approaches and observations shows (1) a persistent large uncertainty in the estimate of land-use change emissions, (2) a low agreement between the different methods on the magnitude of the land CO 2 flux in the northern extratropics, and (3) a discrepancy between the different methods on the strength of the ocean sink over the last decade. This living data update documents changes in the methods and data sets used in this new global carbon budget and the progress in understanding of the global carbon cycle compared with previous publications of this data set. The data presented in this work are available at https://doi.org/10.18160/GCP-2022 (Friedlingstein et al., 2022b).

Basic Concepts and Models for Interpreter and Translator Training is a systematically corrected, enhanced and updated avatar of a book (1995) which is widely used in T&I training programmes worldwide and widely quoted in the international Translation Studies community. It provides readers with the conceptual bases required to understand both the principles and recurrent issues and difficulties in professional translation and interpreting, guiding them along from an introduction to fundamental communication issues in translation to a discussion of the usefulness of research about Translation, through discussions of loyalty and fidelity issues, translation and interpreting strategies and tactics and underlying norms, ad hoc knowledge acquisition, sources of errors in translation, T&I cognition and language availability. It takes on board recent developments as reflected in the literature and spells out and discusses links between practices and concepts in T&I and concepts and theories from cognitive psychology and psycholinguistics.

France has been heavily affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and went into lockdown on 17 March 2020. Using models applied to hospital and death data, we estimate the impact of the lockdown and current population immunity. We find that 2.9% of infected individuals are hospitalized and 0.5% of those infected die (95% credible interval: 0.3 to 0.9%), ranging from 0.001% in those under 20 years of age to 8.3% in those 80 years of age or older. Across all ages, men are more likely to be hospitalized, enter intensive care, and die than women. The lockdown reduced the reproductive number from 2.90 to 0.67 (77% reduction). By 11 May 2020, when interventions are scheduled to be eased, we project that 3.5 million people (range: 2.1 million to 6.0 million), or 5.3% of the population (range: 3.3 to 9.3%), will have been infected. Population immunity appears to be insufficient to avoid a second wave if all control measures are released at the end of the lockdown.

Numerous machine learning (ML) approaches have been proposed for automatic classification of Alzheimer's disease (AD) from brain imaging data. In particular, over 30 papers have proposed to use convolutional neural networks (CNN) for AD classification from anatomical MRI. However, the classification performance is difficult to compare across studies due to variations in components such as participant selection, image preprocessing or validation procedure. Moreover, these studies are hardly reproducible because their frameworks are not publicly accessible and because implementation details are lacking. Lastly, some of these papers may report a biased performance due to inadequate or unclear validation or model selection procedures. In the present work, we aim to address these limitations through three main contributions. First, we performed a systematic literature review. We identified four main types of approaches: i) 2D slice-level, ii) 3D patch-level, iii) ROI-based and iv) 3D subject-level CNN. Moreover, we found that more than half of the surveyed papers may have suffered from data leakage and thus reported biased performance. Our second contribution is the extension of our open-source framework for classification of AD using CNN and T1-weighted MRI. The framework comprises previously developed tools to automatically convert ADNI, AIBL and OASIS data into the BIDS standard, and a modular set of image preprocessing procedures, classification architectures and evaluation procedures dedicated to deep learning. Finally, we used this framework to rigorously compare different CNN architectures. The data was split into training/validation/test sets at the very beginning and only the training/validation sets were used for model selection. To avoid any overfitting, the test sets were left untouched until the end of the peer-review process. Overall, the different 3D approaches (3D-subject, 3D-ROI, 3D-patch) achieved similar performances while that of the 2D slice approach was lower. Of note, the different CNN approaches did not perform better than a SVM with voxel-based features. The different approaches generalized well to similar populations but not to datasets with different inclusion criteria or demographical characteristics. All the code of the framework and the experiments is publicly available: general-purpose tools have been integrated into the Clinica software (www.clinica.run) and the paper-specific code is available at: https://github.com/aramis-lab/AD-DL.

Louis Martin, Benjamin Muller, Pedro Javier Ortiz Suárez, Yoann Dupont, Laurent Romary, Éric de la Clergerie, Djamé Seddah, Benoît Sagot. Proceedings of the 58th Annual Meeting of the Association for Computational Linguistics. 2020.

Accurate assessment of anthropogenic carbon dioxide (CO 2 ) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate is critical to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe and synthesize datasets and methodologies to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO 2 emissions ( E FOS ) are based on energy statistics and cement production data, while emissions from land-use change ( E LUC ) are based on land-use and land-use change data and bookkeeping models. Atmospheric CO 2 concentration is measured directly, and its growth rate ( G ATM ) is computed from the annual changes in concentration. The global net uptake of CO 2 by the ocean ( S OCEAN , called the ocean sink) is estimated with global ocean biogeochemistry models and observation-based f CO 2 products ( f CO 2 is the fugacity of CO 2 ). The global net uptake of CO 2 by the land ( S LAND , called the land sink) is estimated with dynamic global vegetation models. Additional lines of evidence on land and ocean sinks are provided by atmospheric inversions, atmospheric oxygen measurements, and Earth system models. The sum of all sources and sinks results in the carbon budget imbalance ( B IM ), a measure of imperfect data and incomplete understanding of the contemporary carbon cycle. All uncertainties are reported as ±1 σ . For the year 2023, E FOS increased by 1.3 % relative to 2022, with fossil emissions at 10.1 ± 0.5 GtC yr −1 (10.3 ± 0.5 GtC yr −1 when the cement carbonation sink is not included), and E LUC was 1.0 ± 0.7 GtC yr −1 , for a total anthropogenic CO 2 emission (including the cement carbonation sink) of 11.1 ± 0.9 GtC yr −1 (40.6 ± 3.2 GtCO 2 yr −1 ). Also, for 2023, G ATM was 5.9 ± 0.2 GtC yr −1 (2.79 ± 0.1 ppm yr −1 ; ppm denotes parts per million), S OCEAN was 2.9 ± 0.4 GtC yr −1 , and S LAND was 2.3 ± 1.0 GtC yr −1 , with a near-zero B IM (−0.02 GtC yr −1 ). The global atmospheric CO 2 concentration averaged over 2023 reached 419.31 ± 0.1 ppm. Preliminary data for 2024 suggest an increase in E FOS relative to 2023 of +0.8 % (−0.2 % to 1.7 %) globally and an atmospheric CO 2 concentration increase by 2.87 ppm, reaching 422.45 ppm, 52 % above the pre-industrial level (around 278 ppm in 1750). Overall, the mean of and trend in the components of the global carbon budget are consistently estimated over the period 1959–2023, with a near-zero overall budget imbalance, although discrepancies of up to around 1 GtC yr −1 persist for the representation of annual to semi-decadal variability in CO 2 fluxes. Comparison of estimates from multiple approaches and observations shows the following: (1) a persistent large uncertainty in the estimate of land-use change emissions, (2) low agreement between the different methods on the magnitude of the land CO 2 flux in the northern extra-tropics, and (3) a discrepancy between the different methods on the mean ocean sink. This living-data update documents changes in methods and datasets applied to this most recent global carbon budget as well as evolving community understanding of the global carbon cycle. The data presented in this work are available at https://doi.org/10.18160/GCP-2024 (Friedlingstein et al., 2024).

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.

Musically trained and untrained listeners were required to listen to 27 musical excerpts and to group those that conveyed a similar emotional meaning (Experiment 1). The groupings were transformed into a matrix of emotional dissimilarity that was analysed through multidimensional scaling methods (MDS). A 3-dimensional space was found to provide a good fit of the data, with arousal and emotional valence as the primary dimensions. Experiments 2 and 3 confirmed the consistency of this 3-dimensional space using excerpts of only 1 second duration. The overall findings indicate that emotional responses to music are very stable within and between participants, and are weakly influenced by musical expertise and excerpt duration. These findings are discussed in light of a cognitive account of musical emotion.

Abstract The article is an effort to discuss ten major dilemmas of peace research as the field has evolved over the last 25 years: the definition of peace research; peace as absence of violence (including structural violence); violence as obstacles to basic needs satisfaction; extension to peace in nature, human and social spaces (not only the global space); the dialectic between research, education and action; the social role of the peace researcher; the basic strategies of peace action; the methods of peace research; the choice of intellectual style; the conception of peace in various civilizations. The central conclusion is that the basic concern of peace research is the reduction of violence of all kinds; this is done by progressively removing barriers in space (transnational, global studies), in the organization of knowledge (transdisciplinary, holistic studies), in time (integrating empirical studies of the past, critical studies of the present and constructive studies for the future). As such peace research can also be seen as an effort, along with development, future and woman studies, to counteract fragmentation in the social sciences.

às quais agradecemos imensamente.

In this paper we provide a detailed account of the various realizations of the accentual phrase in our phonological model of French intonation (Jun & Fougeron 1995, 2000), and introduce a slight revision in tone-syllable association. In addition to the default and unmarked phrases, we examine the intonational contour of long polymorphemic words and utterances containing a sequence of several clitics. We discuss the status of additional H tones found in the marked phrases and the constraints on the distribution of these H tones.

Feature economy is a principle of sound systems according to which languages tend to maximise the ratio of sounds over features. The major goal of this study is to confirm the predictions of feature economy at the synchronic level, using an objective sampling technique applied to a genetically and areally balanced sample of the world's languages. It also shows that feature economy can be used as a tool in phonological feature analysis, and offers voiced aspirates, voiceless sonorants and various types of glottalised sounds as illustrations. Feature economy applies not only to distinctive feature values, but to redundant values of features that are distinctive or phonologically active elsewhere in the system. Feature economy cannot be reduced to a purely phonetic principle of gesture economy, but may reflect a general principle of linguistic organisation according to which the active categories of a grammatical system tend to be used to maximal effect.

Is there a universal hierarchy of the senses, such that some senses (e.g., vision) are more accessible to consciousness and linguistic description than others (e.g., smell)? The long-standing presumption in Western thought has been that vision and audition are more objective than the other senses, serving as the basis of knowledge and understanding, whereas touch, taste, and smell are crude and of little value. This predicts that humans ought to be better at communicating about sight and hearing than the other senses, and decades of work based on English and related languages certainly suggests this is true. However, how well does this reflect the diversity of languages and communities worldwide? To test whether there is a universal hierarchy of the senses, stimuli from the five basic senses were used to elicit descriptions in 20 diverse languages, including 3 unrelated sign languages. We found that languages differ fundamentally in which sensory domains they linguistically code systematically, and how they do so. The tendency for better coding in some domains can be explained in part by cultural preoccupations. Although languages seem free to elaborate specific sensory domains, some general tendencies emerge: for example, with some exceptions, smell is poorly coded. The surprise is that, despite the gradual phylogenetic accumulation of the senses, and the imbalances in the neural tissue dedicated to them, no single hierarchy of the senses imposes itself upon language.

Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as "molecular margins" and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection.

Résumé Par sa prise en compte des effets concomitants des catégories sociales de race, de classe et de genre, l’intersectionnalité s’est vue hissée au rang de plus importante contribution théorique du féminisme à ce jour. Si les premiers travaux intersectionnels (états-uniens et britanniques) ont fait sortir de l’invisibilité le locus social des femmes s’auto-identifiant comme black ou de couleur , les travaux contemporains dépassent les confins de l’aire anglophone et visent de plus en plus l’élaboration d’un instrument intersectionnel en vue de transformer les politiques de justice sociale et les dispositifs de lutte contre les discriminations. Ce projet suscite deux types de débats : l’un portant sur la production des savoirs intersectionnels et la manière de mener une recherche dans ce domaine, l’autre sur l’utilisation de ces savoirs dans les combats politiques pour l’égalité. Se limitant au premier débat, le présent article s’efforce de dégager les principaux points de tension dans les théorisations actuelles de l’intersectionnalité. Son objectif est double : montrer certaines limites du pouvoir explicatif de l’intersectionnalité, et proposer des pistes à la lumière des discussions déjà engagées. Pour ce faire, quatre points y sont abordés : l’intersectionnalité comme paradigme de recherche, la question des niveaux d’analyse, le différend théorique sur le statut ontologique des catégories de différence, et la question de l’élargissement de la portée théorique de l’intersectionnalité.

Squamous cell carcinoma of the hypopharynx represents a distinct clinical entity. Most patients present with significant comorbidities and advanced-stage disease. The overall survival is relatively poor because of high rates of regional and distant metastasis at presentation or early in the course of the disease. A multidisciplinary approach is crucial in the overall management of these patients to achieve the best results and maintain or improve functional results. Traditionally, operable hypopharyngeal cancer has been treated by total (occasionally partial) laryngectomy and partial or circumferential pharyngectomy, followed by reconstruction and postoperative radiotherapy in most cases. Efforts to preserve speech and swallowing function in the surgical treatment of hypopharyngeal (and laryngeal) cancer have resulted in a declining use of total laryngopharyngectomy and improved reconstructive efforts, including microvascular free tissue transfer. There are many surgical, as well as nonsurgical, options available for organ and function preservation, which report equally effective tumor control and survival. The selection of appropriate treatment is of crucial importance in the achievement of optimal results for these patients. In this article, several aspects of surgical and nonsurgical approaches in the treatment of hypopharyngeal cancer are discussed. Future studies must be carefully designed within clearly defined populations and use uniform terminology and standardized functional assessment and declare appropriate patient or disease endpoints. These studies should focus on improvement of results, without increasing patient morbidity. In this respect, technical improvements in radiotherapy such as intensity-modulated radiotherapy, advances in supportive care, and incorporation of newer systemic agents such as targeted therapy, are relevant developments.

High-throughput CRISPR-Cas9 screens have recently emerged as powerful tools to decipher gene functions and genetic interactions. Here we use a genome-wide library of guide RNAs to direct the catalytically dead Cas9 (dCas9) to block gene transcription in Escherichia coli. Using a machine-learning approach, we reveal that guide RNAs sharing specific 5-nucleotide seed sequences can produce strong fitness defects or even kill E. coli regardless of the other 15 nucleotides of guide sequence. This effect occurs at high dCas9 concentrations and can be alleviated by tuning the expression of dCas9 while maintaining strong on-target repression. Our results also highlight the fact that off-targets with as little as nine nucleotides of homology to the guide RNA can strongly block gene expression. Altogether this study provides important design rules to safely use dCas9 in E. coli.

Abstract The growing need to store an increasing amount of renewable energy in a sustainable way has rekindled interest for sodium-ion battery technology, owing to the natural abundance of sodium. Presently, sodium-ion batteries based on Na3V2(PO4)2F3/C are the subject of intense research focused on improving the energy density by harnessing the third sodium, which has so far been reported to be electrochemically inaccessible. Here, we are able to trigger the activity of the third sodium electrochemically via the formation of a disordered NaxV2(PO4)2F3 phase of tetragonal symmetry (I4/mmm space group). This phase can reversibly uptake 3 sodium ions per formula unit over the 1 to 4.8 V voltage range, with the last one being re-inserted at 1.6 V vs Na+/Na0. We track the sodium-driven structural/charge compensation mechanism associated to the new phase and find that it remains disordered on cycling while its average vanadium oxidation state varies from 3 to 4.5. Full sodium-ion cells based on this phase as positive electrode and carbon as negative electrode show a 10–20% increase in the overall energy density.

BACKGROUND: The efficacy of preventing perinatal transmission (PT) of human immunodeficiency virus type 1 (HIV-1) depends on both viral load (VL) and treatment duration. The objective of this study was to determine whether initiating highly active antiretroviral therapy (ART) before conception has the potential to eliminate PT. METHODS: A total of 8075 HIV-infected mother/infant pairs included from 2000 to 2011 in the national prospective multicenter French Perinatal Cohort (ANRS-EPF) received ART, delivered live-born children with determined HIV infection status, and did not breastfeed. PT was analyzed according to maternal VL at delivery and timing of ART initiation. RESULTS: The overall rate of PT was 0.7% (56 of 8075). No transmission occurred among 2651 infants born to women who were receiving ART before conception, continued ART throughout the pregnancy, and delivered with a plasma VL <50 copies/mL (upper 95% confidence interval [CI], 0.1%). VL and timing of ART initiation were independently associated with PT in logistic regression. Regardless of VL, the PT rate increased from 0.2% (6 of 3505) for women starting ART before conception to 0.4% (3 of 709), 0.9% (24 of 2810), and 2.2% (23 of 1051) for those starting during the first, second, or third trimester (P < .001). Regardless of when ART was initiated, the PT rate was higher for women with VLs of 50-400 copies/mL near delivery than for those with <50 copies/mL (adjusted odds ratio, 4.0; 95% CI, 1.9-8.2). CONCLUSIONS: Perinatal HIV-1 transmission is virtually zero in mothers who start ART before conception and maintain suppression of plasma VL.